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Optimization of Automated Radiosynthesis of Gallium-68-Labeled PSMA11 with Two [Ge]Ge/[Ga]Ga Generators: Fractional Elution or Prepurification?
Pharmaceuticals (Basel)
November 2023
Institute of Pharmacy, CHU Lille, F-59000 Lille, France.
Prostate cancer is one of the most common forms of cancer in men. An imaging technique for its diagnosis is [Ga]-prostate-specific membrane antigen ([Ga]Ga-PSMA-11) positron emission tomography (PET). To address the increasing demand for [Ga]-labeled peptides and reduce the cost of radiosynthesis, it is therefore necessary to optimize the elution process of [Ge]Ge/[Ga]Ga generators.
View Article and Find Full Text PDFComparing the effects of various (p,xn) radionuclide production routes on induced radioactivity in the concrete walls of a cyclotron vault.
Radiat Prot Dosimetry
October 2023
Institute of Nuclear Engineering and Science, National Tsing Hua University, 101, Sec. 2, Kuang-Fu Road, Hsinchu 30013, Taiwan, R.O.C.
In sum, 11 (p,xn) related nuclear reactions with 9 target materials, namely 18O(p,n)18F, 15N(p,n)15O, 68Zn(p,n)68Ga, 68Zn(p,2n)67Ga, 69Ga(p,2n)68Ge, 89Y(p,n)89Zr, 100Mo(p,pn)99Mo, 100Mo(p,2n)99mTc, 112Cd(p,2n)111In, 124Xe(p,2n)123Cs and 203Tl(p,3n)201Pb, are involved in the operation of 13 radionuclide-production cyclotrons in Taiwan. The secondary neutrons accompanying these production routes could induce varying degrees of material activation in the cyclotron facility. Accordingly, this study compared the effects of various (p,xn) production routes on the neutron-induced long-lived radioactivity in the concrete walls of a hypothetical cyclotron vault.
View Article and Find Full Text PDFAutomated synthesis and quality control of [Ga]Ga-PentixaFor using the Gaia/Luna Elysia-Raytest module for CXCR4 PET imaging.
EJNMMI Radiopharm Chem
February 2023
Cochin Hospital, Assistance Publique Hôpitaux de Paris, 123 Boulevard de Port Royal, 75014, Paris, France.
Background: [Ga]Ga-PentixaFor is a promising radiotracer for positron emission tomography imaging of several human tumors overexpressing the chemokine receptor-4 (CXCR4). CXCR4 overexpression has been demonstrated in patients with hematologic malignancies, solid cancers, as well as cardiovascular pathologies of inflammatory origins. However, its radio synthesis is not yet fully developed in France, and existing methods do not use our type of synthesis module.
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