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Gonadotropins, local factors and a variety of adipokines contribute to regulate swine granulosa cell function.
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Dipartimento di Scienze Medico-Veterinarie, Università di Parma, Via del Taglio 10, 43126, Parma, Italy.
This paper reviews the role of endocrine regulators in swine ovarian cell functions, highlighting the intricate hormonal interactions that drive reproductive and metabolic processes. The pig represents a valuable model for human biology due to physiological and anatomical similarities. Understanding the endocrine mechanisms in swine can provide insights about human reproductive health and metabolic disorders.
View Article and Find Full Text PDFMechanisms of Lipid-Associated Macrophage Accrual in Metabolically Stressed Adipose Tissue.
Bioessays
January 2025
Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Division of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria.
Adipose tissue (AT) inflammation, a hallmark of the metabolic syndrome, is triggered by overburdened adipocytes sending out immune cell recruitment signals during obesity development. An AT immune landscape persistent throughout weight loss and regain constitutes an immune-obesogenic memory that hinders long-term weight loss management. Lipid-associated macrophages (LAMs) are emerging as major players in diseased, inflamed metabolic tissues and may be key contributors to an obesogenic memory in AT.
View Article and Find Full Text PDFExploring the Link Between Psoriasis and Adipose Tissue: One Amplifies the Other.
Int J Mol Sci
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Unit of Dermatology, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Psoriasis and obesity, while distinct, are inter-related inflammatory conditions. Adipose tissue (AT)-derived mediators could be pathogenically active in triggering and/or amplifying psoriatic skin inflammation and, vice versa, skin inflammation could drive increased adiposity that triggers the development of several chronic conditions. Gaining insight into their intricate relationship could be essential for effective management and treatment.
View Article and Find Full Text PDFObesity is a metabolic disease that is marked by excessive fat accumulation and is objectively defined as a body mass index (BMI) ≥30 kg/m2. Obesity is associated with several other comorbidities, including psoriasis, which is a chronic autoimmune skin disease. Adipocytes produce pro-inflammatory signaling molecules, namely adipokines and classic cytokines, that drive increased inflammation axnd may contribute to the pro-inflammatory pathways driving psoriasis disease pathogenesis.
View Article and Find Full Text PDFCell-to-cell and organ-to-organ crosstalk in the pathogenesis of alcohol-associated liver disease.
eGastroenterology
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Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Alcohol-associated liver disease (ALD) is a growing global health concern and its prevalence and severity are increasing steadily. While bacterial endotoxin translocation into the portal circulation is a well-established key factor, recent evidence highlights the critical role of sterile inflammation, triggered by diverse stimuli, in alcohol-induced liver injury. This review provides a comprehensive analysis of the complex interactions within the hepatic microenvironment in ALD.
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