Melioidosis is an endemic disease in southeast Asia and northern Australia, caused by Burkholderia pseudomallei. A typhoon-related outbreak occurred in southern Taiwan in July 2005. High mortality in melioidosis associated with bacteremic pneumonia and septic shock. We report a patient with life-threatening melioidosis who developed rapid progression of bacteremic pneumonia with acute respiratory distress syndrome, septic shock and multiple organ dysfunction and was successfully treated with recombinant human activated protein C (rhAPC) and meropenem. Although rhAPC has been reported to reduce the mortality of severe septic shock caused by various pathogens, to our best knowledge, this is the first reported case of rhAPC application in life-threatening melioidosis.
Melioidosis is a severe tropical disease linked to the bacterium Burkholderia pseudomallei, which uses host cell mechanisms for mobility.
The study examined genetic variations of BimA and BimC in B. pseudomallei by analyzing 1,294 clinical isolates from northeast Thailand between 2015 and 2018.
Results showed conserved 3D structures of BimA and BimC variants across strains and confirmed their ability to form plaques and develop actin tails in host cells, providing insights into their role in bacterial virulence.
Chagas disease, melioidosis, and Legionnaires' disease are serious infections that create an urgent need for new treatments, targeting a specific protein called MIP.
Researchers found that inhibiting MIP proteins, which have a particular enzyme activity, significantly reduces the ability of these pathogens to survive and invade cells.
Through various advanced techniques, they identified strong inhibitors of MIPs with very low concentrations needed for effective action, highlighting the potential of these inhibitors in developing treatment strategies.
Melioidosis, an infectious disease caused by Burkholderia pseudomallei, is prevalent in Southeast Asia and Northern Australia, presenting various clinical manifestations from asymptomatic to life-threatening infections. Although primarily affecting the lungs, intra-abdominal viscera, and musculoskeletal system, melioidosis can rarely involve the heart and mediastinum, which pose significant diagnostic and therapeutic challenges. Herein, we present the case of a 53-year-old male farmer who presented with persistent fever and chest pain, progressing to pericarditis and cardiac tamponade.
Background: Melioidosis, a life-threatening infection caused by the gram negative bacterium Burkholderia pseudomallei, can involve almost any organ. Bone and joint infections (BJI) are a recognised, but incompletely defined, manifestation of melioidosis that are associated with significant morbidity and mortality in resource-limited settings.
Methodology/principal Findings: We identified all individuals with BJI due to B.
Melioidosis is a potentially life-threatening infection. This study aimed to assess the melioidosis knowledge among distinct participant groups in the tropical Top End of the Northern Territory (NT) of Australia. Participants were categorised into three groups: NT medical students and health research staff (Group 1: Hi-Ed), Aboriginal Rangers and Aboriginal Healthcare Workers (Group 2: Rangers/AHWs), and patients with a history of melioidosis infection (Group 3: Patients).
