Human diseases are a significant cause of suffering and mortality and lead to a consequential need for effective therapies. The need for therapy is as old as human history itself. Therapy has progressed from an age of administration of herbal remedies and organ extracts to an era of serendipitous drug discovery, when the pharmaceutical industry was born, to the dominance of medicinal chemistry and more recently, to the revolutionary advances--genetic engineering and monoclonal antibody technology, high-speed technologies, gene therapy and the deciphering of the human genome--which promise the discovery of completely new targets for new medicines as well as the great potential of personalized therapy.
Download full-text PDF |
Source |
---|
Microbiol Spectr
February 2023
Centre for Environmental Biotechnology, School of Natural Sciences, Bangor University, Bangor, Gwynedd, United Kingdom.
Within months of the COVID-19 pandemic being declared on March 20, 2020, novel, more infectious variants of SARS-CoV-2 began to be detected in geospatially distinct regions of the world. With international travel being a lead cause of spread of the disease, the importance of rapidly identifying variants entering a country is critical. In this study, we utilized wastewater-based epidemiology (WBE) to monitor the presence of variants in wastewater generated in managed COVID-19 quarantine facilities for international air passengers entering the United Kingdom.
View Article and Find Full Text PDFChest
December 2022
Division of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD.
Background: Combination intrapleural fibrinolytic and enzyme therapy (IET) has been established as a therapeutic option in pleural infection. Despite demonstrated efficacy, studies specifically designed and adequately powered to address complications are sparse. The safety profile, the effects of concurrent therapeutic anticoagulation, and the nature and extent of nonbleeding complications remain poorly defined.
View Article and Find Full Text PDFCrit Care Explor
July 2021
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH.
Objectives: Overutilization of laboratory services is now recognized as harmful to patients and wasteful. In fact, the American Board of Internal Medicine's Choosing Wisely campaign recommends against ordering routine testing that does not answer a clinical question. Per peer benchmarking, our institution as a whole occupied an extreme outlier position at the 100th percentile for laboratory utilization.
View Article and Find Full Text PDFMicroorganisms
January 2021
Department of Animal Science, Division of Agriculture, University of Arkansas, Fayetteville, AR 72701, USA.
Feed additives have been suggested to improve animal growth performance through modulating the gut microbiota. The hypothesis of this study was that the combination of two organic acids would exert synergistic effects on the growth performance and gut microbiota of weaning pigs. To test this hypothesis, we followed 398 weaning pigs from two university experiment stations (University of Illinois at Urbana-Champaign (UIUC) and University of Arkansas (UA)) to determine the effects of increasing levels (0%, 0.
View Article and Find Full Text PDFMicroorganisms
January 2020
Department of Animal Science, Division of Agriculture, University of Arkansas, Fayetteville, AR 72701, USA.
Zinc has been very efficacious in reducing post-weaning diarrhea, whereas animal-derived peptides are suggested to improve the growth performance of weaned piglets. However, the combined effect of zinc and peptides on swine production and swine gut microbiota is still largely unknown. In this study, we followed 288 nursery pigs from the age of d30 to d60 to evaluate the growth performance and gut microbiota of weanling pigs subjected to different levels of a fish-porcine-microbial peptide cocktail (0.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!