AI Article Synopsis
- The study aimed to assess the levels of Bcl-2 protein expression in rat brains following a concussion.
- The researchers used immunohistochemistry to examine the cortex, pontine, and cerebellum regions, finding no Bcl-2 expression in healthy control rats.
- In concussion-affected rats, Bcl-2 protein levels were detected one hour post-injury, peaked four days later, and then gradually declined, indicating its potential as a diagnostic marker for concussions and assessing recovery time.
Article Abstract
Objective: To evaluate the expression of Bcl-2 protein after brain concussion.
Methods: Expression levels of Bel-2 protein in cortex, pontine and cerebellum of rats were investigated using immunohistochemistry.
Results: There was no expression of Bcl-2 protein in control group seen. The expression of Bcl-2 protein in brain concussion groups was detected at l hour, and the expression level reached its peak 4 days after the concussion and then declined gradually.
Conclusion: Our findings suggest that the detection of Bel-2 protein could be an indicator for diagnosis of brain concussion and for estimation of the post injury time interval.
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