The design of artificial molecular machines is complicated because the mechanics used in macromachines is not readily adaptable for nano environments. We constructed a semi-artificial molecular device, which contains a naturally occurring molecular machine-a vaccinia virus encoded protein-linked with an artificial part. The self-assembled construct makes two fluorescently labeled detector units. It is the first sensor capable of selectively detecting different types of DNA breaks, exemplifying a practical approach to the design of molecular devices.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805678 | PMC |
| http://dx.doi.org/10.1021/nl048357e | DOI Listing |
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