Objective: To compare the frequency and magnitude of head impacts between National Collegiate Athletic Association Division I and American high school football players. The long-term goal is to correlate impact forces with injury patterns, leading to improvements in protective headgear.
Methods: The helmets of football players at the University of Oklahoma (n = 40) and Casady High School (n = 16) were instrumented with the Head Impact Telemetry System (Simbex, Lebanon, NH). Data were collected for practices and games for the 2005 football season and were analyzed by player position and school. Player positions were separated into two groups (skill and line) for analysis. Two case studies of athletes who sustained a concussion are also presented.
Results: A total of 54,154 impacts were recorded at the University of Oklahoma and 8326 at Casady High School. College players sustained high-level impacts greater than 98 g more frequently than high school players. The mean linear accelerations for the top 1, 2, and 5% of all impacts were also higher for college players (P < 0.02). Skill position players received 24.6% of all impacts and sustained an impact greater than 98 g once every 70 impacts. In contrast, linemen sustained the highest number of impacts, but most were relatively low-magnitude (20-30 g). Linemen sustained an impact greater than 98 g once every 125 impacts.
Conclusion: Differences in the frequency and magnitude of head acceleration after impact exist between a Division I college team and a high school team. Compared with linemen, skill position players typically sustain the highest-level impacts. Additional data collection and analysis are required to correlate concussion diagnosis with acceleration magnitude and impact location.
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Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, United States.
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February 2025
Graduate School, Fujian University of Traditional Chinese Medicine, Fuzhou City, People's Republic of China.
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South University School of Pharmacy, Savannah, Giorgia, USA.
KRAS is a proto-oncogene that is found to be mutated in 15% of all metastatic cancers with high prevalence in pancreatic, lung, and colorectal cancers. Additionally, patients harboring KRAS mutations respond poorly to standard cancer therapy. As a result, KRAS is seen as an attractive target for targeted anticancer therapy.
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