Purpose: To determine whether the sequence of training to obtain MD and PhD degrees is associated with different career paths for physicians who have their PhD before medical school and those who obtain it after their MD, and to explore the factors that encourage or dissuade Canadian dual-degree physicians in pursuing a research career.
Method: In 2003, questionnaires from the University of Alberta, Edmonton, Canada, were sent to all 734 Canadian physicians having MDs and PhDs, identified through the Canadian Medical Directory. Data collected were gender; year and country of MD; sequence of obtaining degrees; portion of time on clinical, research, teaching, and administrative duties; number of publications and currently held grant amounts; and perceived incentives and disincentives to research careers. Two focus groups were held with a subset of physicians to further explore themes.
Results: The response rate was 64%. On the basis of the timing of the PhD relative to the MD, physicians were designated early PhDs (26%), concurrent PhDs (12%), or late PhDs (62%). Late PhDs spent more time in research and less time on clinical practice than the other two groups and spent more time teaching and had published more papers than the early PhDs. Grant amounts were highest for late PhDs. Lack of time and resources were the major disincentives to research, and noteworthy incentives were the opportunity for intellectual challenge and creativity, and previous research experience.
Conclusions: Physicians who obtain a PhD after an MD have a more research-focused career than those who enter medical school with a PhD.
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http://dx.doi.org/10.1097/ACM.0b013e3180308155 | DOI Listing |
Int J Mol Sci
September 2023
College of Horticulture, Shanxi Agricultural University, Jinzhong 030801, China.
Chalcone synthase (CHS) is the first key enzyme-catalyzing plant flavonoid biosynthesis. Until now, however, the blueberry CHS gene family has not been systematically characterized and studied. In this study, we identified 22 genes that could be further classified into four subfamilies from the highbush blueberry () genome.
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September 2022
Department of Cardiology, Zhongda Hospital, Southeast University, Nanjing, China.
Obstructive sleep apnea (OSA) accelerates the progression of chronic heart failure (CHF). OSA is characterized by chronic intermittent hypoxia (CIH), and CIH exposure accelerates cardiac systolic dysfunction and cardiac remodeling in a cardiac afterload stress mouse model. Mechanistic experiments showed that long-term CIH exposure activated hypoxia-inducible factor 1α (HIF-1α) expression in the mouse heart and upregulated miR-29c expression and that both HIF-1α and miR-29c simultaneously inhibited sarco-/endoplasmic reticulum calcium ATPase 2a (SERCA2a) expression in the mouse heart.
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October 2021
Department of Medicine, Section of Athero & Lipo, Baylor College of Medicine, Houston, TX 77030, USA; Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:
Cardiac metabolism is a high-oxygen-consuming process, showing a preference for long-chain fatty acid (LCFA) as the fuel source under physiological conditions. However, a metabolic switch (favoring glucose instead of LCFA) is commonly reported in ischemic or late-stage failing hearts. The mechanism regulating this metabolic switch remains poorly understood.
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July 2021
Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
Front Med (Lausanne)
April 2020
Centre Hospitalier de Lannemezan, Lannemezan, France.
Recently, disulfiram has been proposed as a promising treatment for people suffering from persistent symptoms of Lyme Disease. Disulfiram has several distinct molecular targets. The most well-known is alcohol dehydrogenase, a key enzyme for detoxifying the organism after alcohol ingestion.
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