An important factor in effective stimulation of the retina is close contact with the retina. The design of the electrode surface and the placement of the electrode against the retina both affect the degree of contact with the retina. We have addressed the design factor by creating a curved surface 3200-electrode array. The placement factor we have addressed by use of an impedance sensitive feedback from the array. The feedback is in the form of an image showing contact with the retina, where greater pixel intensity indicates greater impedance and thus closer contact with the retina. In this paper, we present qualitative and quantitative assessments of the relationship between impedance and the device output as well as an in vivo demonstration of contact imaging. In addition, we evaluated the three-dimensional profile of the stimulation voltage distribution to assess the importance of close retinal contact for high resolution stimulation.
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http://dx.doi.org/10.1088/1741-2560/4/1/S03 | DOI Listing |
Eye Contact Lens
January 2025
UPMC Eye Center (J.L.O., L.Z., A.M., E.G.R., R.M.Q.S., D.K.D.), University of Pittsburgh School of Medicine, Pittsburgh, PA; Charles T. Campbell Laboratory of Ophthalmic Microbiology (A.M., E.G.R., R.M.Q.S., D.K.D.), Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA; Associated Retina Consultants (J.L.O.), Phoenix, AZ; and San Antonio Eye Center (J.W.), San Antonio, TX.
Objective: To compare endophthalmitis rates after cataract extraction in patients with different preoperative prophylaxis: double povidone-iodine preparation with topical antibiotics versus a control group.
Methods: All cases of postoperative endophthalmitis over the last 17 years were reviewed. Incidence rates of endophthalmitis for all cataract surgeries (current procedural terminology codes 66982 and 66984) performed by 26 surgeons were calculated.
Int J Retina Vitreous
January 2025
Department of Ophthalmology and Visual Sciences, Federal University of São Paulo (UNIFESP), Rua Botucatu, 822, Vila Clementino, São Paulo/SP, 04023-062, Brazil.
Background: Ozurdex® (Allergan®, AbbVie Company, North Chicago, Illinois, EUA), is composed of 0.7 mg of dexamethasone, fused in a solid biodegradable PLGA polymer, whose degradation occurs naturally in the vitreous cavity, usually in six months after its application.
Methods: In this study, we included patients aged ≥ 18 years with one or two eyes who had an indication for Ozurdex implants.
Retina
October 2024
Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Purpose: The research investigates the efficacy of hydroxypropyl methylcellulose (HPMC) treatment in facilitating the development of compact water droplets on the rear surface of synthetic lenses with capsule imperfections during the process of fluid-air exchange.
Method: This study examined four patients with intraocular lens (IOL) implants and posterior capsule defects who experienced the formation of dense water droplets on the posterior surface following fluid-air exchange. When this occurrence obstructs fundus visualization during surgery, it is recommended to suspend the surgical procedure.
J Cell Sci
January 2025
Sorbonne Université, INSERM, CNRS, Institut de la Vision, F-75012 Paris, France.
Signal transduction downstream of axon guidance molecules is essential for steering developing axons. Second messengers including cAMP are key molecules shared by a multitude of signaling pathways and are required for a wide range of cellular processes including axon pathfinding. Yet, how these signaling molecules achieve specificity for each of their downstream pathways remains elusive.
View Article and Find Full Text PDFbioRxiv
December 2024
Department of Ophthalmology, School of Medicine, University of California San Francisco, San Francisco, CA, USA.
Diverse retinal ganglion cells (RGCs) transmit distinct visual features from the eye to the brain. Recent studies have categorized RGCs into 45 types in mice based on transcriptomic profiles, showing strong alignment with morphological and electrophysiological properties. However, little is known about how these types are spatially arranged on the two-dimensional retinal surface-an organization that influences visual encoding-and how their local microenvironments impact development and neurodegenerative responses.
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