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Vulvar Epidermolytic Hyperkeratosis: A Comprehensive Systematic Review of Case Reports and Series.
J Clin Med
December 2024
Department of Oncologic Dermatology-Elias Emergency University Hospital, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
: Vulvar epidermolytic hyperkeratosis (EHK) is an exceedingly rare dermatological condition, often presenting as solitary or multiple lesions in the vulvar region. Due to its clinical resemblance to other vulvar disorders, such as condyloma acuminatum, Bowenoid papulosis, and squamous cell carcinoma, vulvar EHK poses significant diagnostic challenges. While individual case reports and small case series have documented instances of vulvar EHK, comprehensive studies systematically consolidating the clinical, histopathological, and therapeutic aspects of this condition remain lacking.
View Article and Find Full Text PDFAMPylation is a post-translational modification involving the transfer of adenosine monophosphate (AMP) from adenosine triphosphate (ATP) to target proteins, serving as a critical regulatory mechanism in cellular functions. This study aimed to expand the phenotypic spectrum associated with mutations in the FICD gene, which encodes an adenyltransferase enzyme involved in both AMPylation and deAMPylation. A clinical evaluation was conducted on a patient presenting with a complex clinical profile.
View Article and Find Full Text PDFModern Digital Query Analytics of Patient Education Materials on Acanthosis Nigricans: Systematic Search and Content Analysis.
JMIR Dermatol
January 2025
Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN, United States.
Background: Online digital materials are integral to patient education and health care outcomes in dermatology. Acanthosis nigricans (AN) is a common condition, often associated with underlying diseases such as insulin resistance. Patients frequently search the internet for information related to this cutaneous finding.
View Article and Find Full Text PDFAddressing the cardiovascular implications of acanthosis nigricans: what a dermatologist needs to know.
Dermatol Online J
October 2024
Campbell University School of Medicine, Leon Levine Hall of Medical Sciences.
Background: Acanthosis nigricans (AN) is a dermatologic skin condition that is often overlooked in its role as an indicator of underlying cardiovascular disorders. Recognizing the importance of AN beyond its cosmetic concerns is crucial for improving patient outcomes.
Objective: Provide a review of AN and what every dermatologist should know of its underlying cardiovascular risk.
Prevalence of Clinical Manifestations Known to Be Associated With Insulin Resistance Among Female Medical Students of a Private College in Saudi Arabia.
Cureus
November 2024
Family and Community Medicine, Ibn Sina National College for Medical Studies, Jeddah, SAU.
Article Synopsis
- Insulin resistance is linked to various chronic diseases, highlighting a concerning trend for future health issues, particularly within the Saudi population where data is insufficient.
- A study surveyed 272 female medical students in Jeddah to assess symptoms associated with insulin resistance, measuring physical metrics and utilizing questionnaires to gather data.
- Results showed significant correlations between certain skin conditions like acanthosis nigricans and waist circumference as indicators of insulin resistance, while conditions like acne and others were not linked, alongside higher incidences of cravings and daytime sleepiness among participants.
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