Nicorandil decreases cardiac events during and after noncardiac surgery.

Satoshi Kashimoto Makoto Seki Toshihiko Ishiguro Hitoshi Yoshioka Osamu Nagata Kinya Nishimura Toshihiro Kikuchi Tatsuya Yamada Motoyo Iwade Akibumi Omi Osamu Honda Atsuhiro Sakamoto Yukihiko Ogihara Keiko Fujimoto Yasushi Nakaigawa Jitsu Kato Akio Watanabe Minoru Nomura Junzo Takeda

J Clin Anesth

Department of Anesthesiology, Faculty of Medicine, University of Yamanashi, Tamaho, Yamanashi 409-3898, and Department of Anesthesia, Cancer Institute Hospital, Tokyo, Japan.

Published: February 2007

The study aimed to determine if nicorandil decreases the chances of cardiac events in patients at intermediate risk during and after noncardiac surgeries.
Conducted in 13 hospitals in Japan, the research included patients with heart-related risk factors like angina and diabetes mellitus, who received nicorandil during surgery.
Results showed that patients treated with nicorandil experienced significantly fewer cardiac events both during surgery and in the following days, indicating its potential benefits for at-risk patients.

Study Objective: To assess whether nicorandil reduces the likelihood of cardiac events during and after intermediate risk surgery.

Design: Multicenter study.

Setting: 13 hospitals in Japan.

Patients: Intermediate-risk patients were identified by the presence of risk factors such as angina, a history of myocardial infarction, heart failure, diabetes mellitus, and abnormal electrocardiography (ECG).

Interventions: Nicorandil was given to these patients during the operation.

Measurements And Main Results: Cardiac events during the operation and the following 5 days were monitored. The frequency of cardiac events in nicorandil-treated patients was compared with those in nontreated patients. Eighty-four patients received nicorandil during surgery and 237 patients received standard care. Cardiac events in the nicorandil-treated group occurred less frequently both during the operation (odds ratio, 0.15; 95% confidence interval, 0.03-0.76; P=0.02) and after it (odds ratio, 0.24; 95% confidence interval, 0.06-0.90; P=0.04).

Conclusions: Nicorandil reduces the frequency of cardiac events in patients undergoing noncardiac surgery, both during and after the operation.

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http://dx.doi.org/10.1016/j.jclinane.2006.05.023	DOI Listing

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