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Formulation and evaluation of herbal essential oil based nail lacquer for management of onychomycosis.
J Mycol Med
December 2024
Chitkara College of Pharmacy, Chitkara University, Punjab, 140401, India. Electronic address:
Introduction: Onychomycosis (Paronychia) is a common fungal nail infection, characterised by thickened, discoloured and brittle nails often accompanied by pain and discomfort. It is one of the most prevalent fungal nail infections with the global incidence of >20 % affected commonly by Candida albicans and Candida parapsilosis. The market today is flooded with various antifungal therapies (Azoles, Imidazoles, Allylamines, etc.
View Article and Find Full Text PDFNociceptive TRP channels function as molecular target for several antifungal drugs.
Fundam Clin Pharmacol
December 2024
Department of Veterinary Pharmacology, Faculty of Agriculture, Tottori University, Tottori, Japan.
Background/objectives: Topically applied antifungal agents can induce adverse effects, such as pain and irritation. The transient receptor potential (TRP) channels-TRPA1 and TRPV1-mainly expressed in sensory neurons, act as sensors for detecting irritants. This study aims to evaluate the involvement of nociceptive channels in topical antifungal-induced pain and irritation.
View Article and Find Full Text PDFTerbinafine Resistance in Strains Isolated from Humans and Animals: A Retrospective Cohort Study in Italy, 2016 to May 2024.
J Clin Med
September 2024
Clinica Dermatologica di Terni, Dipartimento di Medicina e Chirurgia, Università degli Studi di Perugia, 06123 Perugia, Italy.
Article Synopsis
- Globalization and migration have led to an increase in the spread of dermatophytes, which are highly contagious fungal infections that can seriously impact quality of life due to symptoms like itching and burning.
- The DermaGenius Resistance Multiplex PCR assay was used to test 172 strains from humans and animals for terbinafine resistance, revealing that while all animal strains were sensitive, a notable percentage (5.6%) of human strains showed resistance.
- The study emphasizes the rising concern over antifungal resistance and underscores the importance of the One Health concept, particularly regarding the role of emerging dermatophyte species in public health.
Bioinformatics Approaches in the Development of Antifungal Therapeutics and Vaccines.
Curr Genomics
May 2024
Centre for Biotechnology, M.D. University, Rohtak, Haryana, India.
Fungal infections are considered a great threat to human life and are associated with high mortality and morbidity, especially in immunocompromised individuals. Fungal pathogens employ various defense mechanisms to evade the host immune system, which causes severe infections. The available repertoire of drugs for the treatment of fungal infections includes azoles, allylamines, polyenes, echinocandins, and antimetabolites.
View Article and Find Full Text PDFNovel targets and improved immunotherapeutic techniques with an emphasis on antimycosal drug resistance for the treatment and management of mycosis.
Heliyon
August 2024
Department of Physiology, Bankura Christian College, Bankura, West Bengal, 722101, India.
Infections due to pathogenic fungi are endemic in particular area with increased morbidity and mortality. More than a thousand people are infected per year and the way of treatment is of high demand having a significant impact on the population health. Medical practitioners confront various troublesome analytic and therapeutical challenges in the administration of immunosuppressed sufferer at high danger of expanding fungal infections.
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