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http://dx.doi.org/10.1371/journal.pcbi.0030012 | DOI Listing |
Intensive Care Med
November 2024
Department of Neonatal and Pediatric Intensive Care, Division of Neonatology, Erasmus MC, University Medical Center-Sophia Children's Hospital, Rotterdam, The Netherlands.
Hum Vaccin Immunother
December 2023
Center for Systems Immunology, Departments of Immunology and Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA.
A significant surge in research endeavors leverages the vast potential of high-throughput omic technology platforms for broad profiling of biological responses to vaccines and cutting-edge immunotherapies and stem-cell therapies under development. These profiles capture different aspects of core regulatory and functional processes at different scales of resolution from molecular and cellular to organismal. Systems approaches capture the complex and intricate interplay between these layers and scales.
View Article and Find Full Text PDFBMJ Health Care Inform
February 2022
Department of Adult Intensive Care, Erasmus Medical Center, Rotterdam, The Netherlands.
Objective: Although the role of artificial intelligence (AI) in medicine is increasingly studied, most patients do not benefit because the majority of AI models remain in the testing and prototyping environment. The development and implementation trajectory of clinical AI models are complex and a structured overview is missing. We therefore propose a step-by-step overview to enhance clinicians' understanding and to promote quality of medical AI research.
View Article and Find Full Text PDFIntensive Care Med
July 2021
Department of Adult Intensive Care, Erasmus MC University Medical Center, Room Ne-413, Doctor Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
Purpose: Due to the increasing demand for intensive care unit (ICU) treatment, and to improve quality and efficiency of care, there is a need for adequate and efficient clinical decision-making. The advancement of artificial intelligence (AI) technologies has resulted in the development of prediction models, which might aid clinical decision-making. This systematic review seeks to give a contemporary overview of the current maturity of AI in the ICU, the research methods behind these studies, and the risk of bias in these studies.
View Article and Find Full Text PDFPediatr Crit Care Med
August 2020
Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.
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