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Amyloid β (Aβ) has been confirmed as a therapeutic target in AD by recent findings in Phase 3 trials with anti-Aβ antibodies. Modulators of γ-secretase (GSMs) are an emerging complementary approach to target amyloid. GSMs "modulate" the interaction between γ-secretase and amyloid precursor protein (APP), leading to a reduced production of long, amyloidogenic Aβ42 and Aβ40 and to concomitantly increased levels of the shorter, non amyloidogenic Aβ37 and Aβ38.
View Article and Find Full Text PDFTiming of adjunctive vasopressin initiation for septic shock patients and hospital mortality: A multicentre observational study.
Crit Care Resusc
December 2024
Department of Intensive Care, Austin Hospital, 145 Studley Road, Heidelberg, Victoria, Australia.
Objective: The optimal timing of vasopressin initiation as an adjunctive vasopressor remains unclear. We aimed to study the association between the timing of vasopressin commencement, pre-specified physiological parameters, and hospital mortality.
Design: We conducted a multicentre, retrospective, observational study.
Under-nutrition and its associated factors among adult second-line antiretroviral treatment users in Northern Ethiopia.
BMC Public Health
January 2025
Department of Public Health, Woldia University, Woldia, Ethiopia.
Background: Despite advancements in Human Immunodeficiency Virus (HIV) treatment and care, undernutrition remains a significant concern, accelerating disease progression and risk of Acquired Immune Deficiency Syndrome (AIDS)-related deaths. The nutritional status of second-line antiretroviral treatment (SLART) users in Ethiopia has not been thoroughly investigated. So, this study aimed to assess the nutritional status of HIV/AIDS patients who were on SLART and its associated factors in Northern Ethiopia.
View Article and Find Full Text PDFEffectiveness of an environmental educational program on intern dentists' knowledge and practices regarding eco-friendly green dentistry: a quasi-experimental study.
BMC Med Educ
January 2025
Environmental Health, High Institute of Public Health, Alexandria University, Alexandria, Egypt.
Background: The dental industry is associated with significant environmental impacts so there is a growing need for eco-friendly practices in dentistry. This study aimed to assess dental interns' knowledge and practices regarding eco-friendly dentistry before and after the implementation of the environmental educational program.
Methods: An interventional quasi-experimental study (one group pre-test-post-test design) was conducted on 69 intern dentists at the Faculty of Dentistry Alexandria University.
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