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Vision functionality and user comfort following the use of binocular indirect ophthalmoscope simulator.
Clin Exp Optom
March 2025
Department of Optometry and Vision Science, University of Latvia, Riga, Latvia.
Clinical Relevance: Headset-based simulator training is increasingly utilised in eye care education, offering opportunities to improve clinical skills in a controlled, reproducible environment. These tools support the development of innovative training approaches in eye care.
Background: While the educational advantages of headset-based simulators are recognised, the potential challenges and limitations that users may encounter remain understudied.
Creating a retinal image database to develop an automated screening tool for diabetic retinopathy in India.
Sci Rep
March 2025
Department of Vitreo-Retina, Vision Research Foundation, Sankara Netralaya, Chennai, India.
Diabetic retinopathy (DR), a prevalent microvascular complication of diabetes, is the fifth leading cause of blindness worldwide. Given the critical nature of the disease, it is paramount that individuals with diabetes undergo annual screening for early and timely detection of DR, facilitating prompt ophthalmic assessment and intervention. However, screening for DR, which involves assessing visual acuity and retinal examination through ophthalmoscopy or retinal photography, presents a significant global challenge due to the massive volume of individuals requiring annual reviews.
View Article and Find Full Text PDFCongenital X-linked Retinoschisis (CXLRS) in Indian population. A single center study in 70 eyes.
Am J Ophthalmol
February 2025
Department of Pediatric Retina & Ocular Oncology, Aravind Eye Hospital & Postgraduate Institute of Ophthalmology, Coimbatore, Tamil Nadu.
Background: To study and analyze the demographics, clinical features and surgical indications in Congenital X-linked Retinoschisis (CXLRS) in Indian population.
Design: Retrospective case series.
Methods: It was a retrospective case series in 70 eyes which included all the patients diagnosed with CXLRS.
Gene therapy in children with AIPL1-associated severe retinal dystrophy: an open-label, first-in-human interventional study.
Lancet
February 2025
NIHR Moorfields Biomedical Research Centre, London, UK; UCL Institute of Ophthalmology, University College London, London, UK. Electronic address:
Background: Retinal dystrophy caused by genetic deficiency of AIPL1 causes severe and rapidly progressive impairment of sight from birth. We sought to evaluate whether early intervention by gene supplementation therapy was safe and could improve outcomes in children with this condition.
Methods: This non-randomised, single-arm, clinical study conducted in the UK involved four children aged 1·0-2·8 years with severe retinal dystrophy associated with biallelic disease-causing sequence variants in AIPL1.
From Bench to Bedside: Unraveling Cerebral Malaria and Malarial Retinopathy by Combining Clinical and Pre-Clinical Perspectives.
Curr Eye Res
February 2025
The Wellcome Wolfson Institute For Experimental Medicine, Queen's University Belfast, Belfast, UK.
Infection with carries a significant risk of cerebral malaria (CM). Children are particularly susceptible to human CM (HCM) which manifests as an acute neurovascular encephalopathy leading to high levels of mortality. Occurring in parallel with CM, malarial retinopathy (MR) is readily detected on ophthalmoscopy as one or more of: white-centered retinal hemorrhage, retinal whitening, and vessel discoloration.
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