Introduction: The Deletion (D) rather than Insertion (I) variant of the angiotensin-converting enzyme (ACE) gene is associated with higher circulating ACE activity. Meanwhile, coronary risk rises with the menstrual nadir in oestrogen levels, exogenous oestrogen reduces serum ACE activity (with a greater reduction the higher the baseline ACE activity), and pharmacological reduction in ACE activity is cardioprotective. Alterations in coronary risk associated with the menstrual cycle may thus be mediated through (genotype-dependent) changes in ACE activity. We have examined this hypothesis.
Materials And Methods: Twenty-three healthy female subjects (12 II, 11 DD genotype) were studied. None were taking oral contraceptive agents. Blood was assayed for oestrogen, follicle stimulating hormone (FSH), luteinising hormone (LH), progesterone and ACE activity every three days throughout their menstrual cycle.
Results: ACE activity was unrelated to oestrogen, FSH or LH during the menstrual cycle, irrespective of ACE genotype.
Conclusions: The increase in myocardial ischaemia during low oestrogen phases of the menstrual cycle does not appear mediated through a fall in serum ACE activity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3317/jraas.2006.043 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The ADHD Assessment Quality Assurance Standard for Children and Teenagers (CAAQAS).
Neuropsychiatr Dis Treat
December 2024
Fulbourn Hospital, Cambridgeshire and Peterborough Foundation NHS Trust, Cambridge, UK.
Around 5% of the children and teenagers worldwide are affected by Attention-Deficit/Hyperactivity Disorder [ADHD], making it a major public health concern. Recently, demand for assessments has substantially increased, putting strain on healthcare and waiting lists. There is concern that pressure to clear service bottlenecks is leading to variable quality and reliability of ADHD assessments in this population.
View Article and Find Full Text PDFAntihyperglycemic activity and bioguided isolation of phenolic compounds with antioxidant and cytotoxic properties from Syzygium malaccense leaves.
Fitoterapia
December 2024
Department of Chemistry, Universidade Tecnológica Federal do Paraná (UTFPR), Pato Branco, PR 85503-390, Brazil.
This study investigated the antihyperglycemic potential of a hydroalcoholic extract from Syzygium malaccense leaves (E-SM) and isolate phenolic compounds with antioxidant and cytotoxic activities through a bioguided assay. The aim was to explore the therapeutic properties of S. malaccense in managing hyperglycemia and oxidative stress-related conditions.
View Article and Find Full Text PDFAntihypertensive Effect of Perla and Esmeralda Barley ( L.) Sprouts in an Induction Model with L-NAME In Vivo.
Metabolites
December 2024
Academic Area of Medicine, Institute of Health Sciences, Autonomous University of the State of Hidalgo, Eliseo Ramírez Ulloa 400, Doctores Pachuca, Pachuca 42090, Hidalgo, Mexico.
Hypertension is one of the leading causes of premature death worldwide. Despite advances in conventional treatments, there remains a significant need for more effective and natural alternatives to control hypertension. In this context, sprouted barley extracts have emerged as a potential therapeutic option.
View Article and Find Full Text PDFExploring the efficacy of some biologically active compounds as anti-hypertensive drugs: an insightful evaluation through DFT, molecular docking and molecular dynamics simulations.
In Silico Pharmacol
December 2024
Department of Chemistry, Sidho-Kanho-Birsha University, Purulia, 723104 India.
Unlabelled: Among different anti-hypertensive drugs, calcium channel blockers and human angiotensin-converting enzyme (ACE) inhibitors are the two main types. Herein, we took 25 biologically active ligands with potent anti-hypertensive activities and performed molecular docking studies with the human ACE receptor (PDB ID 1O8A) and human leukocyte antigens (HLA) complex, human voltage-dependent calcium channel alpha1 subunit (PDB ID 3LV3). Beforehand, we had performed density functional theory (DFT) studies to find out their structure-property relationships.
View Article and Find Full Text PDFEvaluating optimal rehabilitation strategies in ICU: study protocol for a multicentre cohort study to assess Physical Activity dosing, Muscle mass, and physICal outcomeS (IPAMICS study).
Ann Clin Epidemiol
October 2024
Department of Critical Care Medicine, Yokohama City University Hospital, Kanagawa, Japan.
Background: Many patients who get discharged from the intensive care unit experience physical dysfunction that persists even after discharge. Physical dysfunction is associated with skeletal muscle atrophy and accompanying intensive care unit-acquired weakness in the early stages of intensive care unit admission, and early diagnosis and prevention with early mobilization are crucial. However, the amount of physical activity required for early mobilization remains controversial in critically ill patients.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!