Objective: Diagnosis of pregnancy-associated osteoporosis is often delayed and therapeutic interventions insufficient.
Study Design: A 28-year-old patient (BMI=18.6) with no additional risks for osteoporosis experienced acute lumbosacral pain two months postpartum, while lactating. After conservative therapy, thoracic and lumbar spine were X-rayed: severe pregnancy-associated osteoporosis with vertebral fractures was diagnosed. 2-year treatment with i. v. bisphosphonate ibandronate was initiated (2 mg every 3 months) and calcium and vitamin D supplementation.
Results: Rapid improvement was observed. Conclusion: In cases with multiple fractures i. v. bisphosphonate leads to substantial decrease of symptoms and further fractures and significant increase of bone mass density (BMD).
Conclusion: In severe cases of pregnancy-associated osteoporosis with multiple fractures i. v. biphosphonate therapy leads to a decrease of symptoms and fracture risk and an increase of bone mass density (BMD).
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This case report illustrates that in vitro fertilization (IVF) may be a potential risk factor for pregnancy-associated osteoporosis (PAO), highlighting the need for awareness and monitoring of bone health in women undergoing IVF treatments. PAO is a rare disease resulting from an imbalance of calcium in the body during pregnancy and lactation and presenting with fragility fractures. PAO occurs in late pregnancy or early postpartum period.
View Article and Find Full Text PDFPregnancy-Associated Osteoporosis - A Rare Cause of Subchondral Fracture of Femoral Head: A Case Report.
J Orthop Case Rep
January 2024
Department of Orthopedics, Government Medical College, Kannur, Kerala, India.
Article Synopsis
- Pregnancy- and lactation-associated osteoporosis (PLAO) is a rare condition that can lead to severe back pain during pregnancy and after childbirth, as demonstrated in a case report of a 19-year-old woman.
- The patient experienced intense back pain and difficulty walking, which was linked to multiple compression fractures and bone issues seen in imaging tests.
- Early diagnosis of PLAO is crucial to prevent serious complications, including vertebral fractures, highlighting the need for awareness among healthcare providers.
Correction to: Subsequent fracture risk of women with pregnancy and lactation-associated osteoporosis after a median of 6 years of follow-up.
Osteoporos Int
December 2023
Faculty of Medicine, Philipps-University of Marburg, Marburg, Germany.
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