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Circulatory CCL2 distinguishes Duchenne muscular dystrophy dogs.
Dis Model Mech
March 2025
Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri, Columbia, MO 65212, USA.
To establish a minimally invasive approach to studying body-wide muscle inflammation in the canine Duchenne muscular dystrophy (DMD) model, we evaluated 13 cytokines/chemokines in frozen sera from 90 affected (239 sera) and 73 normal (189 sera) dogs (0.00 to 45.2 months of age).
View Article and Find Full Text PDFNeurostimulation devices to treat Alzheimer's disease.
Explor Neurosci
February 2025
Department of Electrical and Computer Engineering, Purdue University, Indianapolis, IN 46202, USA.
The use of neurostimulation devices for the treatment of Alzheimer's disease (AD) is a growing field. In this review, we examine the mechanism of action and therapeutic indications of these neurostimulation devices in the AD process. Rapid advancements in neurostimulation technologies are providing non-pharmacological relief to patients affected by AD pathology.
View Article and Find Full Text PDFA randomized multi-arm open labelled comparative clinical trial report of Pankajakasthuri DiabetEaze powder, a novel polyherbal formulation on the nutritional management and glycemic control in type 2 diabetic and prediabetic patients.
Heliyon
February 2025
Pankajakasthuri Herbals India Pvt. Ltd., Poovachal, Trivandrum, India.
Background And Aims: Recently Diabetes Mellitus (DM) has been associated with heightened susceptibility to malnutrition, suggesting that augmenting nutritional intake stands out as a potent therapeutic strategy for addressing malnutrition in individuals with DM. The aim of this clinical investigation was to evaluate the effect of DiabetEaze powder, a polyherbal nutritional formulation developed by us for nutritional management and glycaemic control, on patients with diabetic and prediabetic conditions.
Methods: A total of 143 type II diabetic (T2D) patients who were managing their diabetic condition through modern medicine, AYUSH medicine, lifestyle modification and 68 pre-diabetic patients, aged between 40 and 65 years, were randomly assigned into six groups: control, modern, AYUSH, lifestyle, prediabetic control and prediabetic trial.
Treating critical bone defects by using core-shell biological scaffold to regulate Fibrosis-Osteogenic homeostasis.
Mater Today Bio
April 2025
Department of Orthopedics, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
Critical bone defects pose a significant challenge in the realm of bone defect repair. During the repair process, bone formation is crucial, as the occurrence of invasive tissue growth into the defect, known as fibrosis, is also a possibility. Excessive fibrosis can lead to a "filling effect," wherein fibrous tissue occupies the bone defect area, thereby impeding the bone formation and repair processes.
View Article and Find Full Text PDFAssociation of atrial cardiopathy and residual shunt after patent foramen ovale closure in patients experiencing migraine.
Eur J Med Res
March 2025
Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital of Dalian Medical University, 193 United Road, Dalian, 116021, Liaoning, China.
Aims: Migraine is a prevalent and incapacitating condition. The association between patent foramen ovale (PFO) and migraine-type headaches has been extensively documented. In clinical practice, patients may observe residual shunting after PFO closure.
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