AI Article Synopsis
- Stereotactic radiosurgery is debated in treating cerebral cavernous malformations (CVMs), highlighting the need for more thorough research.
- A study of a thalamic CVM after 40-Gy irradiation showed endothelial cell destruction and significant fibrosis in the surrounding tissue.
- These findings resemble changes seen in arteriovenous malformations post-Gamma Knife surgery, indicating that radiation affects both blood vessels and connective tissue in CVMs.
Article Abstract
Stereotactic radiosurgery is a controversial treatment modality in the management of cerebral cavernous malformations (CVMs). Systematic pathological studies of irradiated specimens probably could help to resolve the controversy. Light microscopic investigation of a surgically resected thalamic CVM 1 year after 40-Gy irradiation revealed endothelial cell destruction in the cavernous channels, and marked fibrosis with scar tissue formation in the connective stroma of the lesion. These histopathological findings were similar to those described in arteriovenous malformations after Gamma Knife surgery, and suggest that the ionizing effect of radiation energy evokes vascular and connective tissue stroma changes in CVMs as well.
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| http://dx.doi.org/10.1159/000100122 | DOI Listing |
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