The asymmetric synthesis of chiral piperazinylpropylisoxazoline analogues, (R)-(+)-1, 2 and (S)-(-)-1, 2 was accomplished through a seven-step sequence of reactions, which involved asymmetric 1,3-dipolar cycloaddition, alkyl chain extension, and reductive amination as key reactions. Chiral ligands (R)-(+)-1, 2 exhibited the higher binding affinity and selectivity for the D(3) receptor over the D(4) receptor than (S)-(-)-1, 2 ligands.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ejmech.2006.12.030 | DOI Listing |
Publication Analysis
Top Keywords
asymmetric synthesis
8
synthesis chiral
8
chiral piperazinylpropylisoxazoline
8
piperazinylpropylisoxazoline ligands
4
ligands dopamine
4
dopamine receptors
4
receptors asymmetric
4
piperazinylpropylisoxazoline analogues
4
analogues r-+-1
4
r-+-1 s---1
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!