We studied the influence of a 3-week hiking vacation at moderate altitude on cardiac pump and endocrine function. 18 males (mean age: 55 years, range 36-60) with metabolic syndrome participated in a 3-week structured guided hiking vacation program (4 times per week at 55-65% of maximal heart rate, total exercise time 29 h). Echocardiography, B-type natriuretic peptide (BNP), NT-proBNP, and endothelin-1 measurements were performed at baseline in Innsbruck (576 m a.s.l., Austria), on the first day at moderate altitude (Obertauern, 1700 m a.s.l., Austria), after 3 weeks in Obertauern, and at follow-up in Innsbruck. We found no adverse cardiovascular effects and no significant changes in echocardiographic measures of systolic or diastolic function, estimated systolic pulmonary artery pressure, exercise capacities, BNP and NT-proBNP, or endothelin-1 concentrations. The blood pressure at rest significantly decreased from baseline to follow-up.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijcard.2006.11.127 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
INTERCEPT-AD, a phase 1 study of intravenous sabirnetug in participants with mild cognitive impairment or mild dementia due to Alzheimer's disease.
J Prev Alzheimers Dis
January 2025
CenExel iResearch, Atlanta, GA, USA.
Background: Soluble species of multimeric amyloid-beta including globular amyloid-beta oligomers (AβOs) and linear amyloid-beta protofibrils are toxic to neurons. Sabirnetug (ACU193) is a humanized monoclonal antibody, raised against globular species of soluble AβO, that has over 650-fold greater binding affinity for AβOs over monomers and appears to have relatively little binding to amyloid plaque.
Objectives: To assess safety, pharmacokinetics, and exploratory measures including target engagement, biomarker effects, and clinical efficacy of sabirnetug in participants with early symptomatic Alzheimer's disease (AD; defined as mild cognitive impairment and mild dementia due to AD).
Cardiopulmonary exercise testing in children and adolescents at moderate altitude: New normative valuesh.
Int J Cardiol
January 2025
Children's Hospital Colorado Heart Institute, Aurora, CO, USA; University of Colorado School of Medicine, Aurora, CO, USA. Electronic address:
Background: Cardiopulmonary exercise tests (CPETs) measure cardiovascular exercise response. Altitude alters exercise parameters, so standard normative datasets (Cooper, Bruce, Burstein) may not accurately predict exercise parameters for data collected at moderate altitude. This study aimed to: 1) establish modern normative exercise values for children/adolescents at moderate altitude and 2) compare these values against the Cooper, Burstein and Bruce models.
View Article and Find Full Text PDFHigh-Throughput Phenotyping for Agronomic Traits in Cassava Using Aerial Imaging.
Plants (Basel)
December 2024
Embrapa Mandioca e Fruticultura, Nugene, Cruz das Almas 44380-000, Bahia, Brazil.
Large-scale phenotyping using unmanned aerial vehicles (UAVs) has been considered an important tool for plant selection. This study aimed to estimate the correlations between agronomic data and vegetation indices (VIs) obtained at different flight heights and to select prediction models to evaluate the potential use of aerial imaging in cassava breeding programs. Various VIs were obtained and analyzed using mixed models to derive the best linear unbiased predictors, heritability parameters, and correlations with various agronomic traits.
View Article and Find Full Text PDFChloroplast arrangement in finger millet under low-temperature conditions.
Biochim Biophys Acta Gen Subj
January 2025
RIKEN Center for Sustainable Resource Science, Yokohama 230-0045, Japan; Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan.
Background: Finger millet, a C plant with mesophyll and bundle sheath cells, has been cultivated at high altitudes in the Himalayas owing to its adaptability to stressful environments. Under environmental stresses such as high light and drought, finger millet mesophyll chloroplasts move toward the bundle sheath, a phenomenon known as aggregative arrangement.
Methods: To investigate the effect of low temperatures on mesophyll chloroplast arrangement in finger millet, we conducted microscopic observations and photochemical measurements using leaves treated at different temperatures in light or darkness, with or without pharmacological inhibitors.
Individual sex-based variability to altitude training in elite badminton players.
J Sports Sci
January 2025
Laboratory Sport, Expertise and Performance (EA 7370), French Institute of Sport, Paris, France.
To assess how altitude training impacts force-velocity-power (F-V-P) profiling and muscular power and anaerobic capacity in elite badminton players in reference to intra- and inter-individual sex-based variability. Following a quasi-experimental design, 14 players (6 females, 8 males) from the French national badminton singles and doubles teams performed a 3-week 'living high-training high' camp at natural altitude (2320 m). F-V-P profile and Wingate anaerobic test were assessed Pre- and Post-intervention, using ANOVA repeated measures conventional statistics, with further estimation statistics to show the magnitude of the testing condition and visualize intra- and inter-individual responses.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!