Background And Purpose: If only a standard electrocardiogram (ECG) is available, at least 25% of patients with long QT syndrome (LQTS) may be missed. Our goal is to quantify abnormal electrical activity and to develop an ECG decision rule for the patients with LQTS.
Methods: One hundred forty-one subjects were included in this study (71 patients with LQTS and 70 healthy subjects). A 12-lead digital ECG was recorded for each subject and analyzed using the CAVIAR (comparative analysis of ECG-VCG and their interpretation with auto-reference to the patient) method.
Results: A decision tree involving criteria based on 3 spatiotemporal ECG measurements-the QT interval and the maximum amplitude of the T wave, both corrected from heart rate, and the loss of planarity of the end of QRS-identified patients with LQTS from healthy subjects with a sensitivity of 89%, a specificity of 96%, and a total accuracy of 92%.
Conclusions: This study suggests that 3-dimensional ECG analysis may improve the detection of patients with LQTS.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jelectrocard.2006.12.014 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Calmodulinopathies are caused by mutations in calmodulin (CaM), and result in debilitating cardiac arrythmias such as long-QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT). In addition, many patients exhibit neurological comorbidities, including developmental delay and autism spectrum disorder. Until now, most work into these mutations has focused on cardiac effects, identifying impairment of Ca /CaM-dependent inactivation (CDI) of Ca 1.
View Article and Find Full Text PDFCongenital Long QT Syndrome Masquerading as Epilepsy: A Case Report.
Cureus
November 2024
Cardiology, Manchester University NHS Foundation Trust, Manchester, GBR.
In this case report, we present a 24-year-old woman with a previous diagnosis of epilepsy who was admitted to the hospital following loss of consciousness (LOC). It was initially assumed that this was an epileptic seizure based on her previous diagnosis of epilepsy; however, a review of her electrocardiograms (ECGs) revealed a prolonged QT interval. She was admitted to the cardiology ward for continuous ECG monitoring and subsequently developed self-limiting torsades de pointes (TDP).
View Article and Find Full Text PDFNovel risk predictor of arrhythmias for patients with potassium channel-related congenital long QT syndrome.
Heart Rhythm
December 2024
Department of Experimental Cardiology, Heart Centre, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands; European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart (ERN GUARD-Heart), Amsterdam, The Netherlands. Electronic address:
Background: Congenital long QT syndrome (LQTS) is characterized by delayed ventricular repolarization, predisposing to potentially lethal ventricular arrhythmias. The variability in disease severity among patients remains largely unexplored, underscoring the limitations of current risk stratification methods.
Objective: We aimed to evaluate the potential utility of electrocardiographic markers from the exercise stress test (EST) in identifying patients with high-risk LQTS.
The Yield of Genetic Testing and Putative Genetic Factors of Disease Heterogeneity in Long QT Syndrome Patients.
Int J Mol Sci
November 2024
National Medical Research Center for Therapy and Preventive Medicine, 101990 Moscow, Russia.
Article Synopsis
- * Among 82 LQTS patients, a 75% diagnostic yield was found in those with high Schwartz scores, while 50% of those with lower scores (<3.5) were diagnosed through broader genetic testing.
- * The findings suggest that the existing LQTS genetic diagnosis framework may not effectively capture cases with lower Schwartz scores, and additional rare variants could indicate more severe disease, pointing towards the need for improved referral criteria.
Coronary artery disease and the risk of life-threatening cardiac events after age 40 in long QT syndrome.
Front Cardiovasc Med
October 2024
Department of Cardiology, Rabin Medical Center, Petah-Tikva and the Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Background And Aims: Long QT syndrome (LQTS) and coronary artery disease (CAD) are both associated with increased risk of ventricular tachyarrhythmia However, there are limited data on the incremental risk conferred by CAD in adult patients with congenital LQTS. We aimed to investigate the risk associated with CAD and life threatening events (LTEs) in patients with LQTS after age 40 years.
Methods: The risk of LTEs (comprising aborted cardiac arrest, sudden cardiac death, or appropriate defibrillator shock) from age 40 through 75 years was examined in 1,020 subjects from the Rochester LQTS registry, categorized to CAD ( = 137) or no-CAD ( = 883) subgroups.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!