Type I cytochrome c(3) is a key protein in the bioenergetic metabolism of Desulfovibrio spp., mediating electron transfer between periplasmic hydrogenase and multihaem cytochromes associated with membrane bound complexes, such as type II cytochrome c(3). This work presents the NMR assignment of the haem substituents in type I cytochrome c(3) isolated from Desulfovibrio africanus and the thermodynamic and kinetic characterisation of type I and type II cytochromes c(3) belonging to the same organism. It is shown that the redox properties of the two proteins allow electrons to be transferred between them in the physiologically relevant direction with the release of energised protons close to the membrane where they can be used by the ATP synthase.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bbabio.2007.01.012 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors.
Front Biosci (Landmark Ed)
January 2025
Division of Molecular Psychiatry, Center of Mental Health, University of Hospital Würzburg, 97080 Würzburg, Germany.
Background: The inheritance of the short allele, encoding the serotonin transporter (SERT) in humans, increases susceptibility to neuropsychiatric and metabolic disorders, with aging and female sex further exacerbating these conditions. Both central and peripheral mechanisms of the compromised serotonin (5-HT) system play crucial roles in this context. Previous studies on SERT-deficient (Sert) mice, which model human SERT deficiency, have demonstrated emotional and metabolic disturbances, exacerbated by exposure to a high-fat Western diet (WD).
View Article and Find Full Text PDFTranscriptome Analysis of and Functional Validation of CYP80s Involved in Benzylisoquinoline Alkaloid Biosynthesis.
Molecules
January 2025
State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
The medicinal plant is rich in aporphine alkaloids, a type of benzylisoquinoline alkaloid (BIA), with aporphine being the representative and most abundant compound, but our understanding of the biosynthesis of BIAs in this plant has been relatively limited. Previous research reported the genome of and preliminarily identified the norcoclaurine synthase (NCS), which is involved in the early stages of the BIA biosynthetic pathways. However, the key genes promoting the formation of the aporphine skeleton have not yet been reported.
View Article and Find Full Text PDFSubacute PM2.5 Exposure Induces Hepatic Insulin Resistance Through Inflammation and Oxidative Stress.
Int J Mol Sci
January 2025
School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, No. 232, East Waihuan Road, Guangzhou Higher Education Mega Centre, Panyu District, Guangzhou 510006, China.
Epidemiological studies prove that type II diabetes, characterized by insulin resistance (IR), may be caused by fine particulate matter 2.5 (PM2.5).
View Article and Find Full Text PDFComparative Genomics Reveals Evidence of the Genome Reduction and Metabolic Potentials of Isolated from Challenger Deep Sediment of the Mariana Trench.
Microorganisms
January 2025
College of Oceanography and Ecological Science, Shanghai Ocean University, Shanghai 201306, China.
Hadal zones account for the deepest 45% of oceanic depth range and play an important role in ocean biogeochemical cycles. As the least-explored aquatic habitat on earth, further investigation is still required to fully elucidate the microbial taxonomy, ecological significance, metabolic diversity, and adaptation in hadal environments. In this study, a novel strain Lsc_1132 was isolated from sediment of the Mariana Trench at 10,954 m in depth.
View Article and Find Full Text PDFRedescription and molecular analysis of Corynosoma pseudohamanni Zdzitowiecki, 1984 (Acanthocephala: Polymorphidae) juveniles from Notothenia coriiceps Richardson in the water area of Argentine Islands, West Antarctica.
Syst Parasitol
January 2025
Molecular Taxonomy Laboratory, Department of Zoology, Chaudhary Charan Singh University, Meerut, Uttar Pradesh, 25004, India.
Corynosoma pseudohamanni Zdzitowiecki, 1984 (Polymorphidae) was described from the intestinal tract of 5 species of seals including the type and main host, the Weddell seal Leptonycotes weddellii (Lesson) in the South Shetlands, West Antarctica. Notothenia coriiceps was the primary paratenic host of 14 fish hosts reported in the original description. We describe excysted juveniles from the body cavity of the major paratenic host, Notothenia coriiceps Richardson collected off Galindez Island, Argentine Islands, West Antarctica for the first time.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!