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Article Synopsis
- Membranous proliferative glomerulonephritis (MPGN) is a rare kidney condition characterized by specific pathological changes, observed in a 77-year-old man with mild proteinuria and hematuria.
- Laboratory tests indicated elevated MPO-ANCA levels and a renal biopsy showed distinct features that confirmed MPGN type 3.
- The patient responded well to treatment with an SGLT2 inhibitor and the case raises questions about the association between high MPO-ANCA levels and latent tuberculosis infection, suggesting a potential link that needs further investigation.*
Garcin Syndrome in a Patient with Hypertrophic Pachymeningitis Following Otitis Media with Antineutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis (OMAAV).
Intern Med
November 2024
Department of Rheumatology, Hamanomachi Hospital, Japan.
A 72-year-old Japanese woman presented to our hospital with progressive hearing loss and dysphagia. Blood tests revealed elevated C-reactive protein and myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA). Contrast-enhanced magnetic resonance imaging of the head showed hypertrophic pachymeningitis of the left middle cranial fossa with compression of the cranial nerves, including the trigeminal (V), facial (VII), glossopharyngeal (IX), and vagal (X) nerves, resulting in cranial nerve palsy.
View Article and Find Full Text PDFMyeloperoxidase Anti-Neutrophil Cytoplasmic Antibody (MPO-ANCA)-Associated Vasculitis With Rare Clinical Manifestations After SARS-CoV-2 Multisystem Inflammatory Syndrome in a 14-Year-Old Boy.
Cureus
August 2024
Allergy and Immunology, Agia Sofia Children's Hospital, Athens, GRC.
Article Synopsis
- Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) microscopic polyangiitis is a serious small vessel vasculitis affecting children, with potential links to SARS-CoV-2 infection and multisystem inflammatory syndrome in children (MIS-C).
- A case study highlights a 14-year-old boy previously diagnosed with MIS-C, who experienced various symptoms including joint pain and kidney issues, coupled with elevated SARS-CoV-2 IgG and MPO-ANCA antibody titers.
- The findings suggest that SARS-CoV-2 and MIS-C might trigger autoimmune vasculitis, but more research is necessary to fully understand this connection.
Causal relationship between immune cells and the risk of myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis: A Mendelian randomization study.
FASEB J
July 2024
Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease categorized as antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. The majority of patients are ANCA-positive, predominantly against myeloperoxidase (MPO). Previous studies have predominantly concentrated on the association between EGPA and neutrophils, but recent research has emphasized the role of lymphocytes in the development of EGPA.
View Article and Find Full Text PDFPrognosis of microscopic polyangiitis is well predictable in the first 2 weeks of treatment.
Clin Exp Nephrol
July 2024
Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Background: Kidney and life outcomes remain unsatisfactory in patients with microscopic polyangiitis (MPA). Appropriate treatment intensity must be provided to the appropriate patients. To identify severe cases early, we investigated the factors related to kidney and life outcomes.
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