AI Article Synopsis
- - Three new polyene antibiotics, mediomycins A and B, and clethramycin, were discovered from the bacterium Streptomyces mediocidicus.
- - Their structures were detailed using NMR studies, chemical reactions, and mass spectrometry analysis.
- - All three compounds exhibited strong antifungal activity in laboratory tests.
Article Abstract
Three polyene antibiotics, mediomycins A (1), B (2), and clethramycin (3), were isolated from Streptomyces mediocidicus ATCC23936. Their structures were elucidated through extensive NMR study coupled with chemical reactions and MS/MS fragmentation analysis. All three compounds are linear polyenes consisting of a conjugated oxo-triene group and a hexaene moiety. Compounds 1 and 2 are new polyenes. All three compounds demonstrated a broad spectrum of antifungal activity in vitro.
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| http://dx.doi.org/10.1021/np060542f | DOI Listing |
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