AI Article Synopsis
- The study aimed to investigate the role of oxidative stress in the salivary glands of patients with Sjogren's syndrome (SS).
- Researchers measured oxidative damage using specific markers in saliva from SS patients and found increased levels of these markers compared to healthy individuals and those with other salivary issues.
- The results suggest that oxidative stress contributes to glandular damage in SS, and measuring these markers could potentially help diagnose the condition.
Article Abstract
Objective: To determine the involvement of oxidative stress in the salivary gland of patients with Sjogren's syndrome (SS).
Methods: Oxidative damage to the gland was measured by 8-hydroxy-2'-deoxyguanosine (8-OHdG) and hexanoyl-lysine (HEL) using the SS saliva. In addition, lactate dehydrogenase (LDH) and mitochondrial glutamic-oxaloacetic transaminase (m-GOT), both general markers for cell damage, were also analyzed.
Results: Increased levels of 8-OHdG and HEL were found in the saliva of SS patients, but not in that of patients with other salivary gland dysfunction or of healthy individuals. Levels of LDH and m-GOT were significantly correlated with 8-OHdG and HEL levels, respectively. Furthermore, the increased levels of 8-OHdG and HEL were also correlated in the SS saliva.
Conclusion: These findings suggested the involvement of oxidative stress in glandular tissue destruction in SS. It was indicated that the detection of 8-OHdG and HEL in the saliva may become a useful tool for the diagnosis of SS.
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| http://dx.doi.org/10.1159/000098211 | DOI Listing |
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