AI Article Synopsis
- Pramipexole, a D3 dopaminergic agonist, significantly improves both sensory and motor symptoms of restless legs syndrome (RLS) based on long-term trials, but its acute effects at low doses were previously unexplored.
- A study involving 10 patients with severe idiopathic RLS evaluated the acute effects of a 0.125 mg dose of pramipexole on symptoms and sleep structure over two nights, with assessments conducted via visual analog scales and polysomnography.
- Findings indicated a notable reduction in both sensory and motor manifestations of RLS, along with enhancements in various sleep parameters following the low-dose pramipexole administration.
Article Abstract
Background: Pramipexole is a D3 dopaminergic agonist that has shown a major effect on both sensory and motor manifestations of restless legs syndrome (RLS) in long-term trials. No data regarding the acute effect of low doses of pramipexole have been reported.
Objective: To evaluate the acute effect of a low dosage of pramipexole (0.125 mg) on sensory symptoms and motor signs of RLS and on the macro- and microstructure of sleep.
Methods: We initially recruited 13 patients affected by severe idiopathic RLS and included 10 of them in our study. For 2 consecutive nights the selected patients were evaluated. Pramipexole 0.125 mg was administered before the second night at 9:00 p.m. A visual analog scale was used to assess the sensory symptoms of RLS. The motor manifestations of RLS and the architecture of sleep were analyzed by polysomnography.
Results: After the acute administration of pramipexole, we observed a significant improvement of the sensory symptoms and motor signs of RLS. Several sleep macrostructure and microstructure parameters improved as well.
Conclusions: Our results suggest that low doses of pramipexole are effective in reducing sensory symptoms and motor signs of RLS, even after the first administration.
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| http://dx.doi.org/10.1159/000099947 | DOI Listing |
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