An island-wide survey of 1081 basic school children, mainly in the age group 2-6 years, is reported. The range of blood lead levels (BLLs) was 1.4 to 202 microg/dL with arithmetic and geometric means of 7.3 microg/dL (standard deviation, 13 microg/dL) and 4.35 microg/dL respectively. Two hundred and thirty children were identified with blood lead levels above 10 microg/dL and among these, 80 were provided with medical attention and of eleven who received chelation, six children were desperately ill from acute lead poisoning necessitating repeated sessions of chelation therapy. The higher blood lead values were found mainly in poor areas of the urban Kingston and St. Andrew Corporate Area, and in St. Catherine where there remain observable though reduced effects from a lead-contaminated area. Environmental interventions, including building an increased national awareness, have also been carried out to reduce the immediate and future dangers of lead poisoning. The most important source of the lead exposure is the recovery of lead from old automobile batteries and even a quite small smelter can contaminate a significant area. Further work is in progress to identify and examine historical and active smelter sites, their possible effects on childhood health, and their remediation.
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http://dx.doi.org/10.1016/j.scitotenv.2006.12.045 | DOI Listing |
Br J Nurs
January 2025
Deputy Corporate Lead Nurse, NHS Blood and Transplant, Lincoln.
Specialist nurses working in Therapeutic Apheresis Services (TAS) at NHS Blood and Transplant participate in an on-call rota. This means working above and beyond their rostered hours and can lead to them working 24 hours in one period. There is a noted risk of fatigue for people who work more than 13 hours in one stretch, and therefore it is important to understand how to recognise and manage the signs of fatigue.
View Article and Find Full Text PDFJ Pediatr Psychol
January 2025
The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, United States.
Objective: Pediatric brain tumor survivors (PBTS) are at risk for neurocognitive late effects that can resemble symptoms of cognitive disengagement syndrome (CDS). In the current study, we compared the CDS symptoms of PBTS to those of healthy comparison classmates (CC) and examined whether CDS might explain group differences in depressive symptoms. We also explored whether CDS symptoms were associated with engagement-based coping strategies and stress responses, thereby testing one mechanism by which CDS could lead to affective difficulties.
View Article and Find Full Text PDFLab Anim
January 2025
Institute of Preclinical Sciences, Veterinary Faculty, University of Ljubljana, Slovenia.
Blood sampling is often performed during animal studies. This is more challenging in mice than in larger animal species owing to their size and lack of blood vessel visibility. Guidelines for blood sampling in mice and papers on animal welfare often refer to the submandibular, cheek, buccal, and anterior facial veins.
View Article and Find Full Text PDFViruses
January 2025
Virology Department, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Cytomegalovirus infections and reactivations are more frequent in people living with HIV (PLWH) and have been associated with increased risk of HIV progression and immunosenescence. We explored the impact of combination antiretroviral therapy (cART) on latent CMV infection in 225 young adults parenterally infected with HIV during childhood. Anti-CMV IgG antibodies were present in 93.
View Article and Find Full Text PDFPharmaceutics
January 2025
Laboratory Medical Immunology, Department of Laboratory Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Multiple Myeloma (MM) is a hematologic malignancy caused by clonally expanded plasma cells that produce a monoclonal immunoglobulin (M-protein), a personalized biomarker. Recently, we developed an ultra-sensitive mass spectrometry method to quantify minimal residual disease (MS-MRD) by targeting unique M-protein peptides. Therapeutic antibodies (t-Abs), key in MM treatment, often lead to deep and long-lasting responses.
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