Many techniques have been advanced to achieve reliable femoral stem fixation in revision total hip arthroplasty. In a cross-sectional study, we compared quality of life in 220 patients with two femoral stem designs: a modular tapered and fluted titanium stem design and a cylindrical extensively coated chrome-cobalt stem with single modularity (head size and neck length alone). We matched cohorts based on age decade and gender. The minimum followup was 1 year with a median of 2 years. Subjective outcome assessment and patient satisfaction were measured using the WOMAC Osteoarthritis Index, the Oxford Hip Score, the SF-12, and the Arthroplasty Satisfaction Scale. At followup, all quality of life measures favored the tapered titanium stem. WOMAC pain, function, and overall scores all were higher in this group. The Oxford Hip Score and the Satisfaction score reflected a greater difference in outcome between the two stem designs. We presume reduced stiffness of the titanium stem, coupled with the intraoperative modularity, resulted in the improved patient outcomes observed in this study.
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http://dx.doi.org/10.1097/01.blo.0000238875.86519.cf | DOI Listing |
J Biomed Mater Res A
January 2025
Faculty of Materials Science and Engineering, Warsaw University of Technology, Warsaw, Poland.
Bone tissue regeneration can be affected by various architectonical features of 3D porous scaffold, for example, pore size and shape, strut size, curvature, or porosity. However, the design of additively manufactured structures studied so far was based on uniform geometrical figures and unit cell structures, which often do not resemble the natural architecture of cancellous bone. Therefore, the aim of this study was to investigate the effect of architectonical features of additively manufactured (aka 3D printed) titanium scaffolds designed based on microtomographic scans of fragments of human femurs of individuals of different ages on in vitro response of human bone-derived mesenchymal stem cells (hMSC).
View Article and Find Full Text PDFMater Today Bio
February 2025
Shanxi Key Laboratory of Biomedical Metal Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan, 030024, China.
Surface nano-modification has emerged as an effective strategy to enhance osseointegration of titanium (Ti) implants. Despite its promise, rational optimization of surface nanomorphology for ameliorated osseointegration remains a significant challenge. Our research pioneering developed a one-step alkali etching technique to produce a gradient nanowire coating with continuously varied dimensions on Ti surfaces, which was subsequently served as a versatile platform for high-throughput screening of optimal dimensions to enhance osseointegration.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Horticultural Science, Faculty of Agriculture, University of Maragheh, Maragheh, 55181-83111, Iran.
Salinity is one of the predominant abiotic stressors that reduce plant growth, yield, and productivity. Ameliorating salt tolerance through nanotechnology is an efficient and reliable methodology for enhancing agricultural crops yield and quality. Nanoparticles enhance plant tolerance to salinity stress by facilitating reactive oxygen species detoxification and by reducing the ionic and osmotic stress effects on plants.
View Article and Find Full Text PDFJ Tissue Viability
December 2024
Institute of Nanoscience & Nanotechnology, Kafrelsheikh University, Kafr ElSheikh, 33516, Egypt; Nile Valley University, Fayoum, 63518 Egypt. Electronic address:
Despite the advances in the development of therapeutic wearable wound-healing patches, lack self-healing properties and strong adhesion to diabetic skin, hindering their effectiveness. We propose a unique, wearable patch made from a 3D organo-hydrogel nanocomposite containing polydopamine, titanium dioxide nanoparticles, and silver quantum dots (PDA-TiO@Ag). The designed patch exhibits ultra-stretchable, exceptional-self-healing, self-adhesive, ensuring conformal contact with the skin even during movement.
View Article and Find Full Text PDFStem Cells Transl Med
December 2024
Department of Orthodontics, Division of Craniofacial and Molecular Genetics, Tufts University School of Dental Medicine, Boston, MA 02111, United States.
The use of dental implants to replace lost or damaged teeth has become increasingly widespread due to their reported high survival and success rates. In reality, the long-term survival of dental implants remains a health concern, based on their short-term predicted survival of ~15 years, significant potential for jawbone resorption, and risk of peri-implantitis. The ability to create functional bioengineered teeth, composed of living tissues with properties similar to those of natural teeth, would be a significant improvement over currently used synthetic titanium implants.
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