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Central Pancreatectomy as a Surgical Alternative for Parenchyma Preservation.
Cureus
December 2024
Department of Hepatobiliary and Pancreatic Surgery, Pontificia Universidad Católica de Chile, Santiago, CHL.
Pancreatoduodenectomy and distal pancreatectomy are standard treatments for various pancreatic pathologies. These procedures involve radical resection and a significant loss of pancreatic tissue, which can lead to exocrine and/or endocrine pancreatic insufficiency. In selected cases of benign tumors or those with low malignant potential, central pancreatectomy can be performed with acceptable morbidity and mortality rates.
View Article and Find Full Text PDFIntraductal Polypoid Neoplasm in the Intrahepatic Large Bile Ducts of Small Duct-type Intrahepatic Cholangiocarcinoma May Result From Cancerization of Ducts.
Am J Surg Pathol
January 2025
Division of Pathology.
Article Synopsis
- A study of 121 cases of small duct-type intrahepatic cholangiocarcinoma (small duct-iCCA) identified intraductal polypoid neoplasms in 8 cases (6.6%), which showed growth patterns adjacent to mass-forming tumors.
- These polypoid neoplasms were found to have histological and immunohistochemical similarities to the primary tumors, indicating a shared biliary subtype and reflecting the cancerization of ductal tissues.
- A comparison with intraductal papillary neoplasm of the bile duct (IPNB) revealed differences, as IPNBs often presented non-invasive characteristics, suggesting that intraductal polypoid neoplasms should
Pre-Surgical Endoscopic Biopsies Are Representative of Esophageal and Esophago-Gastric Junction Adenocarcinoma Histologic Classes and Survival Risk.
Cancers (Basel)
December 2024
Pathology Unit, Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, 16132 Genoa, Italy.
The Esophageal Adenocarcinoma Study Group Europe (EACSGE) recently proposed a granular histologic classification of esophageal-esophago-gastric junctional adenocarcinomas (EA-EGJAs) based on the study of naïve surgically resected specimens that, when combined with the pTNM stage, is an efficient indicator of prognosis, molecular events, and response to treatment. In this study, we compared histologic classes of endoscopic biopsies taken before surgical resection with those of the surgical specimen, to evaluate the potential of the EACSGE classification at the initial diagnostic workup. A total of 106 EA-EGJA cases with available endoscopic biopsies and matched surgical resection specimens were retrieved from five Italian institutions.
View Article and Find Full Text PDFTemozolomide and capecitabine regimen as first-line treatment in advanced gastroenteropancreatic neuroendocrine tumors at a Latin American reference center.
World J Gastrointest Oncol
December 2024
Department of Oncology, Instituto Nacional de Enfermedades Neoplásicas, Lima 15038, Perú.
Background: Numerous studies have indicated that the temozolomide and capecitabine regimen (TEMCAP) exhibits a certain level of efficacy in treating advanced, well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NET). However, published data from Peru are limited. We hypothesize that this regimen could be a viable therapeutic option for advanced GEP-NET in the Peruvian population.
View Article and Find Full Text PDFThe Curious Case of the Disappearing Cancer.
Cureus
November 2024
Internal Medicine, Weiss Memorial Hospital, Chicago, USA.
Esophageal cancer, particularly squamous cell carcinoma, poses significant diagnostic challenges due to its aggressive nature and similarity to metaplastic tissue. Accurate diagnosis often requires multiple biopsies and vigilant surveillance, especially in high-risk individuals with conditions such as gastroesophageal reflux disease (GERD) and a history of smoking. We present a 66-year-old female patient with a history of severe GERD and smoking, who underwent routine endoscopy revealing a gastric cardia nodule.
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