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http://dx.doi.org/10.1213/01.ane.0000255645.64583.e8 | DOI Listing |
Anesth Analg
January 2025
Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.
Background: Sugammadex, aprepitant, and fosaprepitant are increasingly used perioperatively. These medications may interfere with the effectiveness of hormonal contraception. This study assessed anesthesia providers' use of sugammadex and aprepitant, their knowledge of interactions with hormonal birth control, and patient counseling practices to identify possible knowledge gaps or opportunities for practice improvement.
View Article and Find Full Text PDFPaediatr Anaesth
September 2019
Department of Anaesthesia and Pain Medicine, Perth Children's Hospital, Perth, Western Australia, Australia.
Childhood allergy is common, and increasing. Many children are incorrectly labeled as having allergy or adverse drug reactions. This can pose a dilemma for anesthetists and lead to a change in practice or drug selection.
View Article and Find Full Text PDFF1000Res
February 2018
Department of Anesthesiology , Leiden University Medical Center, Leiden, Netherlands.
Muscle relaxation is a routine part of anesthesia and has important advantages. However, the lingering effects of muscle relaxants in the postoperative period have historically been associated with postoperative adverse events. Neuromuscular reversal, together with neuromuscular monitoring, is a recognized strategy to reduce the rate of postoperative residual relaxation but has only marginally improved outcome in the past few decades.
View Article and Find Full Text PDFAnesthesiology
January 2017
From the Department of Anesthesiology, Mayo Clinic College of Medicine, Jacksonville, Florida (S.J.B.); and Boca Raton, Florida (A.F.K.).
Postoperative residual neuromuscular block has been recognized as a potential problem for decades, and it remains so today. Traditional pharmacologic antagonists (anticholinesterases) are ineffective in reversing profound and deep levels of neuromuscular block; at the opposite end of the recovery curve close to full recovery, anticholinesterases may induce paradoxical muscle weakness. The new selective relaxant-binding agent sugammadex can reverse any depth of block from aminosteroid (but not benzylisoquinolinium) relaxants; however, the effective dose to be administered should be chosen based on objective monitoring of the depth of neuromuscular block.
View Article and Find Full Text PDFActa Anaesthesiol Scand
July 2016
Department of General Anesthesiology, Cleveland Clinic, Cleveland, OH, USA.
Background: There is currently a controversy regarding the need for and clinical benefit of maintaining deep neuromuscular block (post-tetanic counts of 1 or 2) vs. moderate block (train-of-four counts of 1-3) for routine laparoscopic surgery. Two recent review articles on this subject arrived at rather different conclusions.
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