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| http://dx.doi.org/10.1136/ard.2006.065102 | DOI Listing |
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Real-world trends in the use of maintenance therapy in ovarian cancer across the United States from 2017 to 2021.
Gynecol Oncol
November 2024
Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:
Objective: We assessed real-world trends in the use of maintenance therapy [MT] (i.e., polyADP-ribose polymerase inhibitors (PARPi) and/or bevacizumab following platinum-based chemotherapy), among U.
View Article and Find Full Text PDFActivation of retinoid X receptors protects retinal neurons and pigment epithelial cells from BMAA-induced death.
Biochim Biophys Acta Mol Cell Res
December 2024
Instituto de Investigaciones Bioquímicas de Bahía Blanca, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur - Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Bahía Blanca, Argentina. Electronic address:
Exposure to the non-protein amino acid cyanotoxin β-N-methylamino-L-alanine (BMAA), released by cyanobacteria found in many water reservoirs has been associated with neurodegenerative diseases. We previously demonstrated that BMAA induced cell death in both retina photoreceptors (PHRs) and amacrine neurons by triggering different molecular pathways, as activation of NMDA receptors and formation of carbamate-adducts was only observed in amacrine cell death. We established that activation of Retinoid X Receptors (RXR) protects retinal cells, including retina pigment epithelial (RPE) cells from oxidative stress-induced apoptosis.
View Article and Find Full Text PDFNew hopes and promises in the treatment of ovarian cancer focusing on targeted treatment-a narrative review.
Front Pharmacol
June 2024
1st Chair and Department of Oncological Gynaecology and Gynaecology, Medical University of Lublin, Lublin, Poland.
Unfortunately, ovarian cancer is still diagnosed most often only in an advanced stage and is also the most lethal gynecological cancer. Another problem is the fact that treated patients have a high risk of disease recurrence. Moreover, ovarian cancer is very diverse in terms of molecular, histological features and mutations.
View Article and Find Full Text PDFA Cyclometalated Ruthenium(II) Complex Induces Oncosis for Synergistic Activation of Innate and Adaptive Immunity.
Angew Chem Int Ed Engl
July 2024
MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, State Key Laboratory of Anti-Infective Drug Discovery and Development, Guangdong Basic Research Center of Excellence for Functional Molecular Engineering, School of Chemistry, Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510006, P. R. China.
Article Synopsis
- An effective cancer chemotherapy should tackle tumor drug resistance while also triggering the body's immune response against cancer cells.
- The study introduces a synthesized Ru(II) complex that induces oncosis by damaging nuclear and mitochondrial DNA, activating cell death pathways, and leading to cell membrane rupture.
- Experimental results show that the Ru(II) complex stimulates both innate and adaptive immune responses, enhancing dendritic cell maturation and promoting the activation of cytotoxic T lymphocytes and M1 macrophages.
Genomic characterization and detection of potential therapeutic targets for peritoneal mesothelioma in current practice.
Clin Exp Med
April 2024
Department of Pathology, Erasmus MC, Rotterdam, the Netherlands.
Peritoneal mesothelioma (PeM) is an aggressive tumor with limited treatment options. The current study aimed to evaluate the value of next generation sequencing (NGS) of PeM samples in current practice. Foundation Medicine F1CDx NGS was performed on 20 tumor samples.
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