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Analytical Insights into Methods for Measuring Ischemia-Modified Albumin.
Molecules
September 2024
Department of Biomedical Sciences, School of Medicine, University of Sassari, 07100 Sassari, Italy.
Ischemia-modified albumin (IMA) has emerged as a pivotal biomarker for the early detection of ischemic conditions, particularly myocardial ischemia, where timely diagnosis is crucial for effective intervention. This review provides an overview of the analytical methods for assessment of IMA, including Albumin Cobalt Binding (ACB), Albumin Copper Binding (ACuB), Enzyme-Linked Immunosorbent Assay (ELISA), new techniques such as liquid crystal biosensors (LCB), quantum dot coupled X-ray fluorescence spectroscopy (Q-XRF), mass spectrometry (MS), and electron paramagnetic resonance (EPR) spectroscopy. Each method was thoroughly examined for its analytical performance in terms of sensitivity, specificity, and feasibility.
View Article and Find Full Text PDFA systematic review and meta-analysis of ischemia-modified albumin in diabetes mellitus.
Heliyon
August 2024
Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Adelaide, Australia.
Aim: There is an ongoing search for novel biomarkers of diabetes. We conducted a systematic review and meta-analysis of the serum concentrations of ischemia-modified albumin (IMA), a candidate biomarker of oxidative stress, acidosis, and ischemia, in patients with pre-diabetes, different types of diabetes mellitus (type 1, T1DM, type 2, T2DM, and gestational, GDM), and healthy controls.
Methods: We searched for case-control studies published in PubMed, Web of Science, and Scopus from inception to December 31, 2023.
Ischemia-modified albumin: is it a promising marker in acute coronary syndrome?
BMC Cardiovasc Disord
August 2024
Department of Medicine, Faculty of Medicine, Wayamba University of Sri Lanka, Kuliyapitiya, Sri Lanka.
Background: Acute coronary syndrome (ACS) is a type of coronary heart disease (CHD), which is responsible for one-third of total deaths in people older than 35 years. Even though cardiac troponin is the gold standard for myocardial necrosis it is blind for ischemia without necrosis. Studies demonstrate that Ischaemia Modified Albumin (IMA) is more sensitive in diagnosing ischemic chest pain compared to cardiac troponin T and electrocardiogram, and its combination with these tests significantly increases the sensitivity for diagnosing unstable angina, non-ST-elevation myocardial infarction (NSTEMI), or ST-elevation myocardial infarction (STEMI), with high positive and negative predictive values, making it a valuable tool for ruling out ACS in patients with inconclusive diagnoses in the emergency department.
View Article and Find Full Text PDFIschemia-modified albumin in rheumatic diseases: A systematic review and meta-analysis.
Immun Inflamm Dis
June 2024
Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
Introduction: The identification of novel, easily measurable disease biomarkers might enhance the diagnosis and management of patients with rheumatic diseases (RDs). We conducted a systematic review and meta-analysis of ischemia-modified albumin (IMA), a marker of oxidative stress, acidosis, and ischemia, in RD patients and healthy controls.
Methods: We searched PubMed, Web of Science, and Scopus from inception to January 15, 2024.
The role of thiol-disulfide homeostasis and ischemia-modified albumin in osteosarcopenia.
Ir J Med Sci
August 2024
Division of Geriatric Medicine, Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey.
Background: Oxidative stress results from an imbalance between the induction of reactive oxygen species and the ability of cells to metabolize them. Numerous markers can be used to assess the level of oxidative stress. Thiol-disulfide homeostasis (TDH) and ischemia-modified albumin (IMA) are some of them.
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