Aim is to study the effect of calcium alginate film (CAF) on guided bone regeneration (GBR). Circular bone defects with 5 mm diameter were created in both tibias in 60 rabbits. The defects covered with CAF served as the experimental site, and with collagen membrane (CM) or with no membrane both served as the control site. Healing was analyzed by gross, X-ray, electromicroscopy, histology, immuno-histochemical studies, and an image pattern analysis system after 1, 2, 4, 6, and 8 weeks. The CM control sites showed more macrophages, and CM were absorbed more slowly while collecting fewer osteoinductive factors (p < 0.01) in the early weeks. CAF induced dense bone formation, whereas CM induced less new bone, and the blank control sites effected the worst. In conclusion, the effect of CAF group gave better results than blank control group and CM group on GBR in this animal model.
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