RAFT polymerization was used to synthesize urea-bearing methyl methacrylate copolymers for binding carboxylate isosteres.
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http://dx.doi.org/10.1039/b613778d | DOI Listing |
Biomaterials
November 2010
IBM Almaden Research Center, 650 Harry Road, San Jose, CA 95120, USA.
Ring-opening polymerization (ROP) of functionalized cyclic carbonates derived from 2,2-bis(methylol)propionic acid (bis-MPA) allows for incorporation of H-bonding urea-functional groups into block copolymers with a potential application of supramolecular drug-delivery systems. The strong H-bonding functionalities of poly(ethylene glycol)-block-poly(ethyl-random-urea carbonate) (PEG-P(E(1-x)-U(x))C) block copolymers not only lowered critical micelles concentration (cmc) of the block copolymer (to 1/4x) in aqueous environment compared to conventional PEG-poly(trimethylene carbonate) (PEG-PTMC) block copolymer without the non-covalent stabilization, but also improved kinetic stability of micelles and Dox-loaded micelles in the presence of a destabilizing agent. It was observed that the incorporation of anticancer drug doxorubicin affected the micellization process of block copolymers in water and caused a sudden increase in sizes of drug-loaded micelles above 200 nm.
View Article and Find Full Text PDFChem Commun (Camb)
March 2007
IBM Almaden Research Center, 650 Harry Road, San Jose, CA 95120, USA.
RAFT polymerization was used to synthesize urea-bearing methyl methacrylate copolymers for binding carboxylate isosteres.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!