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Evaluation of Antipsychotic-Induced Neuroleptic Malignant Syndrome Using a Self-Organizing Map.
Cureus
August 2024
Laboratory of Drug Informatics, Gifu Pharmaceutical University, Gifu, JPN.
Article Synopsis
- * The researchers utilized a self-organizing map (SOM) and decision tree analysis to differentiate between 31 antipsychotics, revealing detailed NMS profiles beyond the usual classifications of typical and atypical antipsychotics.
- * The study analyzed 887,704 reports from the Japanese Adverse Drug Event Report database, providing valuable insights on NMS occurrences with specific antipsychotics to help healthcare providers better manage schizophrenia treatment.
The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology.
Nat Rev Neurol
June 2024
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Increasing appreciation of the phenotypic and biological overlap between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, alongside evolving biomarker evidence for a pre-symptomatic stage of disease and observations that this stage of disease might not always be clinically silent, is challenging traditional views of these disorders. These advances have highlighted the need to adapt ingrained notions of these clinical syndromes to include both the full phenotypic continuum - from clinically silent, to prodromal, to clinically manifest - and the expanded phenotypic spectrum that includes ALS, frontotemporal dementia and some movement disorders. The updated clinical paradigms should also align with our understanding of the biology of these disorders, reflected in measurable biomarkers.
View Article and Find Full Text PDFDiphenhydramine and Migraine Treatment Failure in Pediatric Patients Receiving Prochlorperazine.
Pediatr Emerg Care
August 2024
From the Department of Pediatric Emergency Medicine, Nicklaus Children's Hospital.
Objectives: The objectives are to determine whether diphenhydramine coadministered with prochlorperazine versus prochlorperazine only is associated with a difference in the risk of migraine treatment failure, as measured by the need for additional therapy, hospitalization rates, and 72-hour return rates, and to compare extrapyramidal adverse effects between groups.
Methods: Retrospective cohort of patients aged 7 to 18 years treated in the emergency department for migraines using prochlorperazine with or without diphenhydramine between 2013 and 2019. Patients were included if they had International Classification of Diseases, Ninth or Tenth Revision, codes for migraine or unspecified headache and were treated with prochlorperazine as part of their initial migraine therapy.
Overlaps and divergences between tauopathies and synucleinopathies: a duet of neurodegeneration.
Transl Neurodegener
March 2024
Health Sciences Institute, Key Laboratory of Major Chronic Diseases of Nervous System of Liaoning Province, China Medical University, Shenyang, 110122, China.
Proteinopathy, defined as the abnormal accumulation of proteins that eventually leads to cell death, is one of the most significant pathological features of neurodegenerative diseases. Tauopathies, represented by Alzheimer's disease (AD), and synucleinopathies, represented by Parkinson's disease (PD), show similarities in multiple aspects. AD manifests extrapyramidal symptoms while dementia is also a major sign of advanced PD.
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