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Exploring Immune-Mediated Brain Function Abnormalities in Systemic Lupus Erythematosus: Neuroimaging Evidence of the Impact of Anti-Ribosomal P Protein Antibodies.
Acad Radiol
December 2024
Department of Radiology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China (S.L., S.C., J.X., L.T., X.L.). Electronic address:
Rationale And Objectives: Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the most severe complications of systemic lupus erythematosus (SLE), and its early biomarkers and immune mechanisms remain unclear. This study utilizes Resting-State functional magnetic resonance imaging (rs-fMRI) to explore early neuroimaging biomarkers and potential immune mechanisms of brain injury in SLE, with a particular focus on anti-ribosomal P protein antibody (ARPA).
Materials And Methods: A total of 47 SLE patients and 33 healthy controls (HCs) underwent rs-fMRI.
Exploring cardiovascular implications in systemic lupus erythematosus: A holistic analysis of complications, diagnostic criteria, and therapeutic modalities, encompassing pharmacological and adjuvant approaches.
Biomol Concepts
January 2024
College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, 91766, United States of America.
Systemic lupus erythematosus (SLE) poses a diagnostic challenge due to its heterogeneity. This study examines the cardiac complications of SLE comprehensively, covering pericarditis, myocarditis, pleural effusion, valvular disease, atherosclerosis, and cardiac arrhythmias. Nearly one-third of SLE-related deaths are attributed to cardiovascular diseases, necessitating a deeper understanding of cardiac pathophysiology.
View Article and Find Full Text PDFUnderstanding patient perspectives on health-related searches on the internet: Insights from an online survey of Korean patients with systemic lupus erythematosus.
Lupus
January 2025
Division of Rheumatology, Department of Internal Medicine, Daejeon Rheumatoid & Degenerative Arthritis Center, Chungnam National University Hospital, Daejeon, Republic of Korea.
Background: With the increasing prevalence of digital devices and internet access, digital resources have become essential for educating patients with chronic diseases. We explored the patient perspective on health-related internet searches among Korean patients with systemic lupus erythematosus (SLE).
Methods: We collected data through a Google Survey from 344 SLE patients.
Virome analysis provides new insights into the pathogenesis mechanism and treatment of SLE disease.
Front Cell Infect Microbiol
November 2024
Hunan Provincial Key Laboratory of Medical Virology, College of Biology, Hunan University, Changsha, China.
Article Synopsis
- This study explored the diversity of viruses present in systemic lupus erythematosus (SLE) patients and their potential connection to the disease.
- Researchers analyzed RNA-Seq data from blood samples of 688 SLE patients and 138 healthy controls, discovering ten human virus species, with higher occurrences of certain viruses in SLE patients.
- Findings suggested that infections like HHV5 could worsen SLE symptoms by influencing immune response genes, indicating that SLE patients might be more vulnerable to viral infections compared to healthy individuals.
5-Hydroxymethylcytosine in circulating cell-free DNA as a potential diagnostic biomarker for SLE.
Lupus Sci Med
October 2024
Wenzhou Collaborative Innovation Center of Gastrointestinal Cancer in Basic Research and Precision Medicine, Wenzhou Key Laboratory of Cancer-related Pathogens and Immunity, Department of Microbiology and Immunology, Institute of Molecular Virology and Immunology, Institute of Tropical Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China
Article Synopsis
- Systemic lupus erythematosus (SLE) is a complex autoimmune disease that's hard to diagnose early due to vague symptoms, and current treatments mainly focus on symptom relief rather than a cure.* -
- The study investigates the presence of 5-Hydroxymethylome (5hmC) alterations in plasma cell-free DNA (cfDNA) of SLE patients compared to healthy controls, using advanced profiling techniques to identify specific genomic changes associated with the disease.* -
- Results showed distinct patterns of 5hmC modifications in SLE patients, identifying 151 genes linked to the disease and highlighting the involvement of CTCF in regulating these modifications, which could lead to new diagnostic markers for SLE.*
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