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- The study aimed to identify different phenotypic variants of patients experiencing symptoms related to gastroesophageal reflux disease (GERD), including non-erosive reflux disease (NERD) and functional heartburn (FH), using advanced testing methods like 24-hour pH-impedance and high-resolution esophageal manometry (HSEM).
- A total of 55 symptomatic patients with newly diagnosed GERD and 48 control subjects were analyzed, focusing on their symptoms, medical history, and the results from endoscopic exams, selectively excluding those with erosive esophagitis.
- Results indicated that patients with NERD had the highest number of acid reflux episodes, while those with functional heartburn had the lowest, highlighting a significant
Increased brain iron deposition in the basial ganglia is associated with cognitive and motor dysfunction in type 2 diabetes mellitus.
Brain Res
January 2025
Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jing-wu Road, Jinan, Shandong 250021, China. Electronic address:
Objective: Compared with those in type 2 diabetes mellitus (T2DM) patients without diabetic peripheral neuropathy (DPN), alterations in brain iron levels in the basal ganglia (an iron-rich region) and motor and cognitive dysfunction in T2DM patients with DPN have not been fully elucidated. We aimed to explore changes in brain iron levels in the basal ganglia in T2DM patients with DPN using quantitative susceptibility mapping (QSM).
Methods: Thirty-four patients with DPN, fifty-five patients with diabetes without DPN (non-DPN, NDPN), and fifty-one healthy controls (HCs) were recruited and underwent cognitive and motor assessments, blood biochemical tests, and brain QSM imaging.
Transaortic septal myectomy at the time of aortic valve replacement for severe aortic stenosis: a case series of 55 cases.
Indian J Thorac Cardiovasc Surg
May 2024
Department of Cardiothoracic Surgery, St George's Hospital, London, UK.
Introduction: Symptomatic aortic valve stenosis (AS) is associated with asymmetric basal septal hypertrophy (ABSH) in 10% of cases. In this cohort, it has been suggested that rectification of the left ventricular outflow tract obstruction (LVOTO) by concomitant septal myectomy (CSM) can improve the results of aortic valve replacement (AVR).
Objective: This study aims to present the technique of AVR with CSM for severe AS with ABSH and to determine the associated early and late post-operative outcomes.
Quantitative susceptibility mapping in multiple sclerosis: A systematic review and meta-analysis.
Neuroimage Clin
June 2024
Dept. of Neurology, School of Medicine and Health, Technical University of Munich, Munich, Germany; TUM-Neuroimaging Center, School of Medicine and Health, Technical University of Munich, Munich, Germany. Electronic address:
Background: Quantitative susceptibility mapping (QSM) is a quantitative measure based on magnetic resonance imaging sensitive to iron and myelin content. This makes QSM a promising non-invasive tool for multiple sclerosis (MS) in research and clinical practice.
Objective: We performed a systematic review and meta-analysis on the use of QSM in MS.
Fractal Analysis of Left Ventricular Trabeculae in Patients with End-Stage Renal Disease: A Random Survival Tree Analysis.
J Magn Reson Imaging
November 2024
Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Background: The complexity of left ventricular (LV) trabeculae is related to the prognosis of several cardiovascular diseases.
Purpose: To evaluate the prognostic value of LV trabecular complexity in patients with end-stage renal disease (ESRD).
Study Type: Prospective outcome study.
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