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Serial systemic immune inflammation indices: markers of acute migraine events or indicators of persistent inflammatory status?
J Headache Pain
January 2025
School of Psychology and Public Health, La Trobe University, Melbourne, VIC, 3086, Australia.
Background: Migraine is the most common complex neurological disorder, affecting over a billion people worldwide. Neurogenic inflammation has long been recognized as a key factor in the pathophysiology of migraine though little research has been directed to investigating whether inflammation is greatest in migraine with aura or without, and whether inflammation is a permanent state in migraine or whether is an event related transitory state. Thus, the primary aim of this single-centre, retrospective study was to explore the potential clinical utility of the Serial Systemic Immune-Inflammatory Indices (SSIIi) as a comparative measure of duration and severity of inflammation derived from routine blood cell counts in migraine patients with aura and no-aura both within an acute inpatient setting and as outpatients.
View Article and Find Full Text PDFAnimal welfare assessment after controlled cortical impact in CD-1 mice - A model of posttraumatic epilepsy.
Epilepsy Behav
December 2024
Translational Neuropharmacology Lab, NIFE, Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hannover, Germany. Electronic address:
The ethical use of laboratory animals requires that the benefits of an experimental study are carefully weighed against potential harm to the animals. In traumatic brain injury (TBI) research, ethical concerns are especially relevant to severe TBI, after which animals may experience suffering, depending on the implementation of refinement measures such as (1) postsurgical analgesia during the initial period following TBI and (2) humane endpoints. However, despite the frequent use of rodent models such as fluid percussion injury (FPI) and controlled cortical impact (CCI) in rats or mice, there is only one recent study that applied assessment of welfare to a severe TBI model, the FPI model in rats.
View Article and Find Full Text PDFSevere Periodontitis is Associated With Recurrent Cardiovascular Events-A 10-Year Longitudinal Cohort Study.
J Periodontal Res
November 2024
Department of Operative Dentistry and Periodontology, Martin Luther University Halle-Wittenberg, Halle, Germany.
Aim: The study aimed to elucidate a putative association between severe periodontitis and the incidence of recurrent cardiovascular events in patients with cardiovascular disease (CVD) within 10 years after their initial hospitalisation.
Methods: A cohort of 1002 stationary patients with angiographically proven CVD was included. They were examined regarding prevalence of severe periodontitis (≥ 30% of the teeth with proximal attachment loss of ≥ 5 mm), probing depth, clinical attachment loss, bleeding on probing, number of missing teeth and oral care habits.
Longitudinal Patterns and Predictors of Cognitive Impairment Classification Stability.
Arch Clin Neuropsychol
November 2024
Department of Psychology, University of Victoria, Cornett Building A236, 3800 Finnerty Road (Ring Rd), Victoria, BC, V8P 5C2, Canada.
Objective: Classifications such as Cognitive Impairment, No Dementia (CIND) are thought to represent the transitory, pre-clinical phase of dementia. However, increasing research demonstrates that CIND represents a nonlinear, unstable entity that does not always lead to imminent dementia. The present study utilizes a longitudinal repeated measures design to gain a thorough understanding of CIND classification stability patterns and identify predictors of future stability.
View Article and Find Full Text PDFExtracorporeal Off-Pump Antegrade Cerebral Perfusion in Reconstructive Surgery for Type A Aortic Dissection With Cerebral Malperfusion.
Cureus
October 2024
Department of Cardiovascular Medicine, RUDN University, Moscow, RUS.
Article Synopsis
- TAAD is a severe condition often complicated by CM, which can cause significant neurological damage; CPB and ACP are traditional methods used for cerebral protection during surgery but carry higher risks.
- This study investigates a new off-pump technique using an axillo-axillary shunt to maintain continuous blood flow to the brain during aortic arch surgery for patients with TAAD and CM.
- Results show that this innovative technique provided stable cerebral perfusion without new permanent neurological issues; however, some patients experienced temporary symptoms, and there was a low operative mortality rate of 5.6%.
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