Aim: To investigate the association between chronic periodontitis (CP) and pre-maturity in a group of Brazilian pregnant women from the State of São Paulo.
Materials And Methods: One hundred and twenty-four women were investigated consecutively in a cross-sectional study, between December 2003 and May 2005. Sixty-eight women had pre-term labour (PTL) and 56 had term labour. A periodontal examination was carried out to identify the presence of CP. Statistical analysis used the Fisher's exact test or chi(2) for the discrete variables and the Mann-Whitney test for the non-parametric variables. Odds ratio (OR) was calculated with a 95% confidence interval (CI), to evaluate the relation between CP and pre-maturity.
Results: Periodontal indicators, such as clinical attachment loss (p<0.0001) and bleeding on probing (p=0.012), were observed more in the PTL group. The presence of CP increased the risk for PTL (OR: 4.7, 95% CI: 1.9-11.9), pre-term birth (PTB; OR: 4.9, 95% CI: 1.9-12.8) and low birth weight (<2500 g; OR: 4.2, 95% CI: 1.3-13.3). The pregnant women with PTL presented low levels of schooling (p=0.029) and the lowest number of pre-natal appointments (p=0.0001) when compared with those with term labour.
Conclusion: CP is strongly associated with PTL, PTB and low birth weight in a group of Brazilian pregnant women. These data point to the necessity of regularly investigating CP during pregnancy.
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http://dx.doi.org/10.1111/j.1600-051X.2006.01038.x | DOI Listing |
Aust Dent J
January 2025
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Background: Chronic periodontitis is one of the most common inflammatory diseases worldwide. Micronutrients play a significant impact on health and periodontal disease progression. However, there is still a lack of conclusive studies confirming the causal association of micronutrients with chronic periodontitis.
View Article and Find Full Text PDFImmunopharmacol Immunotoxicol
January 2025
Department of Regenerative Dental Medicine, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Tokushima, Japan.
Objectives: Periodontal disease is a chronic inflammatory disease caused by periodontopathogenic bacteria, and its progression leads to periodontal tissue destruction and tooth loss. Zerumbone is a bioactive substance found in ginger () and is known to have bioactive effects such as anticancer effects, but there have been no attempts to use it for periodontitis treatment. In addition, there have been no reports examining its effects on periodontal tissue component cells.
View Article and Find Full Text PDFBMC Oral Health
January 2025
Department of Life Sciences, GITAM (Deemed to be University), GITAM School of Science, Visakhapatnam, Andhra Pradesh, 530 045, India.
Background: The oral cavity is a complex environment which harbours the second largest and most diverse microflora after the gastrointestinal tract. The bacteriome in the oral cavity plays a pivotal role in promoting the health and well-being of human beings. Gingivitis, an inflammation of the gingival tissue, arises due to plaque accumulation on the teeth, often leads to periodontitis.
View Article and Find Full Text PDFInt J Med Sci
January 2025
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
This study aimed to investigate the involvement of macrophage ferroptosis in chronic apical periodontitis (CAP) and determine if blocking JNK/JUN/NCOA4 axis could alleviate CAP by regulating macrophage ferroptosis. Firstly, the models of apical periodontitis (AP) and models of CAP, including clinical specimens and rats' periapical lesions, were utilized to investigate the role of macrophage ferroptosis in CAP by detecting the ferroptosis related factors. The activation of the JNK/JUN/NCOA4 axis was observed in CAP models.
View Article and Find Full Text PDFJ Indian Soc Periodontol
December 2024
Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta Pusat, Indonesia.
is implicated in periodontitis, a chronic inflammatory disease that destroys the periodontal tissue and alveolar bone due to host-microbe dysbiosis. This study focuses on understanding how contributes to bone destruction in periodontitis. The literature search was conducted using PubMed and Scopus databases based on Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines by entering preselected keyword combinations of inclusion and exclusion criteria.
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