AI Article Synopsis
- Tumors can be targeted by immunotherapy using natural killer (NK) cells, especially when these cells are mismatched for certain molecules and receptors.
- The study evaluated the impact of 28 common chemotherapeutic drugs on the ability of NK cells to kill cancer cells.
- Some drugs like vinblastine and paclitaxel hindered NK cell activity without harming the cells' viability, while others like doxorubicin and 5-fluorouracil allowed NK cells to effectively kill cancer cells even at high concentrations.
Article Abstract
Tumors are considered to be possible targets of immunotherapy using stimulated and expanded autologous or allogeneic natural killer (NK) cells mismatched for MHC class I molecules and inhibitory NK receptors. NK cell-based immunoadjuvant therapies are carried out in combination with standard chemotherapeutic protocols. In the presented study, we characterized the effect of 28 frequently used chemotherapeutic agents on the capacity of NK cells to kill target cells. We found that treatment of NK cells with the drugs vinblastine, paclitaxel, docetaxel, cladribine, chlorambucil, bortezomib, and MG-132 effectively inhibited NK cell-mediated killing without affecting the viability of NK cells. On the other hand, the following drugs permitted efficient NK cell-mediated killing even at concentrations comparable with or higher than the maximally achieved therapeutic concentration in vivo in humans: asparaginase, bevacizumab, bleomycin, doxorubicin, epirubicin, etoposide, 5-fluorouracil, hydroxyurea, streptozocin, and 6-mercaptopurine.
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| http://dx.doi.org/10.1158/1535-7163.MCT-06-0358 | DOI Listing |
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