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Medullary thyroid carcinoma: a 20-year experience from a centre in South India. | LitMetric

AI Article Synopsis

  • The study reviews the management and prognosis of medullary thyroid carcinoma (MTC) at a specific institution over 20 years, focusing on 40 patients, with findings showing both hereditary and sporadic cases.* -
  • Results indicated that the mean age of presentation was 41 years, with most patients undergoing total thyroidectomy and adjuvant therapy, while a significant number experienced postoperative hypercalcitoninaemia.* -
  • The research concluded that MTC is a rare thyroid cancer with specific characteristics, and while the (131)I metaiodobenzylguanidine scan showed promising results, persistent hypercalcitoninaemia indicated a poorer prognosis.*

Article Abstract

Background: Management of medullary thyroid carcinoma (MTC) remains controversial despite many advances over the past five decades. We attempt to review the presentation, management and prognosis of MTC at our institution over the last two decades.

Methods: We conducted a retrospective review of the records of 40 patients with MTC over a period of 20 years.

Results: Ten patients had hereditary MTC and 30 had sporadic MTC. The mean age of presentation was 41 years. Sixty-five per cent of the patients had a definite thyroid swelling and 43% had lymphadenopathy at the time of presentation. Total thyroidectomy with a central neck dissection was carried out in 82.5% of patients. Adjuvant therapy was given in 75% of patients because of extensive/residual disease. Postoperative hypercalcitoninaemia was seen 73% of patients. (131)I metaiodobenzylguanidine scanning was carried out in 16 patients with persistent hypercalcitoninaemia; the uptake was positive in 10 and negative in 6, indicating a positivity of 62%.

Conclusion: Medullary thyroid carcinoma accounts for 2.5% of thyroid carcinomas. There is a small male preponderance. In our series (131)I metaiodobenzylguanidine scan had a better positivity than what has been reported in the published work. Persistent postoperative hypercalcitoninaemia was associated with a poorer prognosis that did not reach statistical significant.

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Source
http://dx.doi.org/10.1111/j.1445-2197.2006.03992.xDOI Listing

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