Tumor necrosis factor-alpha is a central cytokine involved in the regulation of the innate immune response. Signal transducers and activators of transcription 4 and signal transducers and activators of transcription 6 are second messengers mediating the Th1 and Th2-specific immune responses, respectively. We studied the outcome of spinal cord injury with respect to the locomotion and axonal regeneration in tumor necrosis factor-alpha, signal transducers and activators of transcription 4 and signal transducers and activators of transcription 6 knockout mice. Locomotor behavior after injury differed between mouse strains, but not between wild-type and the knockout genotypes of the same strain. Regeneration of descending tracts, assessed by fluorogold/fluororuby retrograde double-labeling, however, appeared hampered by Th2 deficiency.
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