AI Article Synopsis
- The paper discusses the lack of a dynamic model for the gene transfer process using biolistic gene guns, highlighting the need for better understanding and control of the process.
- The authors propose a new model that explores the relationships between penetration depth and factors like helium pressure, acceleration distance, and micro-carrier radius.
- Simulations conducted in the study show strong agreement with previous experimental results, making it a valuable contribution for enhancing the performance of biolistic gene guns.
Article Abstract
The gene transfer process using biolistic gene guns is a highly dynamic process. To achieve good performance, the process needs to be well understood and controlled. Unfortunately, no dynamic model is available in the open literature for analysing and controlling the process. This paper proposes such a model. Relationships of the penetration depth with the helium pressure, the penetration depth with the acceleration distance, and the penetration depth with the micro-carrier radius are presented. Simulations have also been conducted. The results agree well with experimental results in the open literature. The contribution of this paper includes a dynamic model for improving and manipulating performance of the biolistic gene gun.
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| http://dx.doi.org/10.1088/0031-9155/52/5/017 | DOI Listing |
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