State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, PR China.
Published: February 2007
AI Article Synopsis
Article Abstract
Background & Objective: Internal mammary node (IMN) is an important lymphatic metastasis pathway in breast cancer. Its status may affect the staging, treatment, prognosis, and outcome evaluation of breast cancer. This study was to discuss the significance of internal mammary sentinel node biopsy (IMSNB), IMN dissection via intercostal spaces, and IMN micro-metastasis detection in breast cancer.
Methods: A total of 38 consecutive patients with primary breast cancer received mastectomy in Cancer Center of Sun Yat-sen University from Dec. 2004 to May 2006. IMSNB was guided by radionuclide tracking method, followed by IMN dissection via the first to forth intercostal spaces. After routine pathologic examination for all the removed IMNs, the negative ones were submitted to further micro-metastasis detection by immunohistochemistry (IHC) combined with multilayer section technique.
Results: Of the 38 patients, 17 (44.7%) had internal mammary sentinel nodes (IMSNs). Of the 17 patients, 4 had IMSN metastasis detected by routine pathology, 1 had IMSN micro-metastasis, and 2 had isolated tumor cells in IMSNs, while the remaining 10 had no metastasis. The results of IMSNB were accordant to the results of IMN dissection. Of the 21 (55.3%) patients had no IMSN identified, 5 had IMN metastasis by routine pathology after IMN dissection, and 16 had no metastasis.
Conclusions: When IMSNs are identified, they can predict the IMN status well. While for the patients had no IMSN identified, IMN dissection should be performed, especially for those more likely to have metastasis, to decrease the false negative rate. IHC combined with multilayer section technique tends to search out micro-metastasis.
(1) : Cervical arterial dissections (CeAD) are a common cause of stroke in young adults. CeAD can be spontaneous (sCeAD) or traumatic (tCeAD). Whether CeAD subtypes differ in clinical, radiological, and outcome characteristics remains unexplored.
Radical cystectomy (RC) with pelvic lymph node dissection is the standard treatment for patients with limited-stage muscle-invasive bladder cancer. RC is associated with a complication rate of approximately 50-88%. Immunonutrition (IMN) refers to the administration of substrates, such as omega-3 fatty acids, arginine, glutamine, and nucleotides, that modulate the immune response.
The brain is a remarkably complex organ responsible for a wide range of functions, including the modulation of emotional states and movement. Neuronal circuits are believed to play a crucial role in integrating sensory, cognitive, and emotional information to ultimately guide motor behavior. Over the years, numerous studies employing diverse techniques such as electrophysiology, imaging, and optogenetics have revealed a complex network of neural circuits involved in the regulation of emotional or motor processes.
Humeral shaft fracture is a common injury which can be treated either conservatively with functional bracing or with surgical fixation. Current evidence shows an increase in the rate of nonunion after conservative treatment, suggesting that indications for conservative treatment may need to be re-examined. This article updates trends in treatment for humeral shaft fracture.
Videos & Images Theory and Analytics Lab (VITAL), Department of Computer Science, Université de Sherbrooke, Canada; Imeka Solutions inc, Sherbrooke, Canada.
White matter bundle segmentation is a cornerstone of modern tractography to study the brain's structural connectivity in domains such as neurological disorders, neurosurgery, and aging. In this study, we present FIESTA (FIbEr Segmentation in Tractography using Autoencoders), a reliable and robust, fully automated, and easily semi-automatically calibrated pipeline based on deep autoencoders that can dissect and fully populate white matter bundles. This pipeline is built upon previous works that demonstrated how autoencoders can be used successfully for streamline filtering, bundle segmentation, and streamline generation in tractography.
