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The Safety and Efficacy of New DIVA Inactivated Vaccines Against Lumpy Skin Disease in Calves.
Vaccines (Basel)
November 2024
Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise "G. Caporale", 64100 Teramo, Italy.
Lumpy skin disease virus ( family- genus) is the aetiological agent of LSD, a disease primarily transmitted by hematophagous biting, affecting principally cattle. Currently, only live attenuated vaccines are commercially available, but their use is limited to endemic areas. There is a need for safer vaccines, especially in LSD-free countries.
View Article and Find Full Text PDFA Scene Knowledge Integrating Network for Transmission Line Multi-Fitting Detection.
Sensors (Basel)
December 2024
Automation Department, North China Electric Power University, Baoding 071003, China.
Aiming at the severe occlusion problem and the tiny-scale object problem in the multi-fitting detection task, the Scene Knowledge Integrating Network (SKIN), including the scene filter module (SFM) and scene structure information module (SSIM) is proposed. Firstly, the particularity of the scene in the multi-fitting detection task is analyzed. Hence, the aggregation of the fittings is defined as the scene according to the professional knowledge of the power field and the habit of the operators in identifying the fittings.
View Article and Find Full Text PDFPersonalized Secukinumab Treatment in Patients with Plaque Psoriasis Using Model-Informed Precision Dosing.
Pharmaceutics
December 2024
Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, 46100 Valencia, Spain.
Patient care and control of inflammatory disorders, such as psoriasis, can be improved by model-informed precision dosing (MIPD) techniques based on population pharmacokinetic/pharmacodynamic (PK/PD) models. Clinical dose selection decisions based on MIPD strategies need to take account of the uncertainty associated with the individual PK/PD model parameters, which is determined by the quantity of individual observational data collected in clinical practice. The aim of this study was to propose an approach for personalized dosage regimens of secukinumab (SCK) in 22 Spanish patients with plaque psoriasis, whose severity level was considered moderate to severe, taking into account the uncertainty associated with individual parameters in a population-based PK/PD model.
View Article and Find Full Text PDFSoothing the Itch: The Role of Medicinal Plants in Alleviating Pruritus in Palliative Care.
Plants (Basel)
December 2024
Academic Clinical Center of Trás-os-Montes and Alto Douro (CACTMAD), University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.
Chronic pruritus, or persistent itching, is a debilitating condition that severely impacts quality of life, especially in palliative care settings. Traditional treatments often fail to provide adequate relief or are associated with significant side effects, prompting interest in alternative therapies. This review investigates the antipruritic potential of eight medicinal plants: chamomile (), aloe vera (), calendula (), curcumin (), lavender (), licorice (), peppermint (), and evening primrose ().
View Article and Find Full Text PDFVitamin D Status in Roma Mothers and Newborns: Socioeconomic Factors and Impact on Neonatal Outcome.
Nutrients
December 2024
Department of Obstetrics and Gynecology 2, 'George Emil Palade' University of Medicine, Pharmacy, Sciences and Technology of Târgu Mureș, Gheorghe Marinescu Street No. 38, 540136 Târgu Mureș, Romania.
Background: The Roma are a socioeconomically disadvantaged, marginalized community with reduced access to education, social services, and healthcare. Despite the known health risks they are exposed to, we have limited data about a wide range of health outcomes in this population, including vitamin D deficiency. The aim of this study was to investigate prevalence of vitamin D deficiency and its impact on the anthropometric outcomes of newborns in a group of Roma mothers and their infants in Romania.
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