Microbubble spectroscopy of ultrasound contrast agents.

J Acoust Soc Am

Physics of Fluids Group, Department of Science and Technology, University of Twente, PO. Box 217, 7500 AE Enschede, The Netherlands.

Published: January 2007

A new optical characterization of the behavior of single ultrasound contrast bubbles is presented. The method consists of insonifying individual bubbles several times successively sweeping the applied frequency, and to record movies of the bubble response up to 25 million frames/s with an ultrahigh speed camera operated in a segmented mode. The method, termed microbubble spectroscopy, enables to reconstruct a resonance curve in a single run. The data is analyzed through a linearized model for coated bubbles. The results confirm the significant influence of the shell on the bubble dynamics: shell elasticity increases the resonance frequency by about 50%, and shell viscosity is responsible for about 70% of the total damping. The obtained value for shell elasticity is in quantative agreement with previously reported values. The shell viscosity increases significantly with the radius, revealing a new nonlinear behavior of the phospholipid coating.

Download full-text PDF

Source
http://dx.doi.org/10.1121/1.2390673DOI Listing

Publication Analysis

Top Keywords

microbubble spectroscopy
8
ultrasound contrast
8
shell elasticity
8
shell viscosity
8
shell
5
spectroscopy ultrasound
4
contrast agents
4
agents optical
4
optical characterization
4
characterization behavior
4

Similar Publications

Purpose Of Review: Stress urinary incontinence is a growing issue in ageing men, often following treatment for prostate cancer or bladder outflow obstruction. While implantable urological devices offer relief, infections are a significant concern. These infections can lead to device removal, negating the benefits and impacting patient outcomes.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the role of imbalanced gut microbiota in neuromyelitis optica spectrum disorders (NMOSD) and explores the therapeutic potential of GV-971, a drug initially used for Alzheimer's disease, in treating NMOSD.
  • Using an experimental mouse model, researchers injected NMO-IgG and tested GV-971's effects on disease incidence, symptoms, and survival, with positive results compared to a control drug.
  • Results showed that GV-971 significantly reduced NMOSD symptoms and neuroinflammation, improved gut microbiota balance, and lessened peripheral inflammation, suggesting it could be a promising treatment for NMOSD.
View Article and Find Full Text PDF

Enhanced cavitation dose and reactive oxygen species production in microbubble-mediated sonodynamic therapy for inhibition of Escherichia coli and biofilm.

Ultrason Sonochem

May 2024

Department of Applied Physics, School of Science, Harbin University of Science and Technology, Harbin 150080, China; Key Laboratory of Modern Acoustics (MOE), Department of Physics, Collaborative Innovation Center of Advanced Microstructure, Nanjing University, Nanjing 210093, China. Electronic address:

Sonodynamic therapy (SDT) is an emerging antibacterial therapy. This work selected hematoporphyrin monomethyl ether (HMME) as the sonosensitizer, and studied the enhanced inhibition effect of Escherichia coli and biofilm by microbubble-mediated cavitation in SDT. Firstly, the influence of microbubble-mediated cavitation effect on different concentrations of HMME (10 µg/ml, 30 µg/ml, 50 µg/ml) was studied.

View Article and Find Full Text PDF

Hollow-core microstructured optical waveguides (HC-MOW) have recently emerged in sensing technologies, including the gas and liquid detection for industrial as well as clinical applications. Antiresonant HC-MOW provide capabilities for applications in refractive index (RI) sensing, while the long optical path for analyte-light interaction in HC-MOW leads to increased sensitivity of sensor based on Raman scattering signal measurements. In this study, we developed a two-in-one sensor device using HC-MOW for RI and Raman scattering detection.

View Article and Find Full Text PDF

The Green Synthesis of Reduced Graphene Oxide Using Ellagic Acid: Improving the Contrast-Enhancing Effect of Microbubbles in Ultrasound.

Molecules

November 2023

Henan Engineering Technology Research Centre of Ultrasonic Molecular Imaging and Nanotechnology, Henan Provincial People's Hospital, Zhengzhou 450003, China.

There is an urgent need to realize precise clinical ultrasound with ultrasound contrast agents that provide high echo intensity and mechanical index tolerance. Graphene derivatives possess exceptional characteristics, exhibiting great potential in fabricating ideal ultrasound contrast agents. Herein, we reported a facile and green approach to synthesizing reduced graphene oxide with ellagic acid (rGO-EA).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!