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Piezo1 overexpression in the uterus contributes to myometrium contraction and inflammation-associated preterm birth.
J Transl Med
December 2024
Department of Anesthesiology, West China Second University Hospital, Sichuan University, No. 20, Section 3, South of Renmin Road, Chengdu, 610041, Sichuan, China.
Background: Preterm birth, a leading cause of perinatal mortality and morbidity, is often associated with inflammation and aberrant myometrial contractions. This study investigates the role of Piezo1, a mechanosensitive ion channel, in myometrium contraction and inflammation-associated preterm birth.
Methods: We employed Western blotting, Immunofluorescence, and Quantitative real-time PCR techniques to examine Piezo1 expression in uterine tissues.
Vaccination with formulations targeting Eimeria maxima and Clostridium perfringens conferred comprehensive protection using a dual-infection challenge model of necrotic enteritis.
Poult Sci
December 2024
MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China; Animal Biosciences and Biotechnology Laboratory, Beltsville Agricultural Research Center, U.S. Department of Agriculture, Agricultural Research Service, Beltsville, MD 20705, USA. Electronic address:
With increasing regulations restricting antibiotic use in animal feed, the need for alternative strategies to prevent and manage necrotic enteritis (NE) has become imperative. As a result, developing effective vaccines has emerged as a top priority for broiler chicken health management. Coccidial infections are a well-established predisposing factor for NE, underscoring the importance of controlling coccidiosis to help mitigate NE outbreaks.
View Article and Find Full Text PDFEGR1 regulates oral epithelial cell responses to via the EGFR- ERK1/2 pathway.
Virulence
December 2024
Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.
is a fungal pathobiont colonizing mucosal surfaces of the human body, including the oral cavity. Under certain predisposing conditions, invades mucosal tissues activating EGFR-MAPK signalling pathways in epithelial cells via the action of its peptide toxin candidalysin. However, our knowledge of the epithelial mechanisms involved during colonization is rudimentary.
View Article and Find Full Text PDFUnderstanding the role of microbes in health and disease of farmed aquatic organisms.
Mar Life Sci Technol
November 2024
Institute of Biology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, 21941-599 Brazil.
Article Synopsis
- * The impact of environmental changes, like rising temperatures and pollution, can worsen disease conditions in aquaculture by enhancing pathogen virulence.
- * New technologies and biotechnological tools, such as probiotics and metagenomics, are being developed to improve sustainability in aquaculture while reducing the need for antibiotics and better understanding disease mechanisms.
Dynamic driving pressure predicts ventilator-induced lung injury in mice with and without endotoxin-induced acute lung injury.
Am J Physiol Lung Cell Mol Physiol
January 2025
Department of Bioengineering, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States.
Mechanical ventilation (MV) is a necessary lifesaving intervention for patients with acute respiratory distress syndrome (ARDS) but it can cause ventilator-induced lung injury (VILI), which contributes to the high ARDS mortality rate (∼40%). Bedside determination of optimally lung-protective ventilation settings is challenging because the evolution of VILI is not immediately reflected in clinically available, patient-level, data. The goal of this work was therefore to test ventilation waveform-derived parameters that represent the degree of ongoing VILI and can serve as targets for ventilator adjustments.
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