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Nerve Fiber Layer Schisis in Coats Disease.
Retin Cases Brief Rep
December 2024
Casey Eye Institute, Oregon Health & Science University, Portland, OR.
Purpose: To describe two cases of pediatric patients with Coats disease who developed nerve fiber layer (NFL) schisis.
Methods: Observational case series.
Results: Two male pediatric patients, ages 2 and 14, who were being treated for Coats disease were found to have NFL schisis on optical coherence tomography.
Ketamine induces multiple individually distinct whole-brain functional connectivity signatures.
Elife
April 2024
Department of Psychiatry, Yale University School of Medicine, New Haven, United States.
Background: Ketamine has emerged as one of the most promising therapies for treatment-resistant depression. However, inter-individual variability in response to ketamine is still not well understood and it is unclear how ketamine's molecular mechanisms connect to its neural and behavioral effects.
Methods: We conducted a single-blind placebo-controlled study, with participants blinded to their treatment condition.
Accidental substance-related acute toxicity deaths in older adults in 2016 and 2017: a national chart review study.
Health Promot Chronic Dis Prev Can
March 2024
Public Health Agency of Canada, Ottawa, Ontario, Canada.
Article Synopsis
- Limited research on substance-related acute toxicity deaths (ATDs) in older adults in Canada is explored, focusing on their sociodemographic traits, health histories, and circumstances of death.
- A study analyzed coroner and medical examiner files from 2016 to 2017, identifying 705 accidental ATDs in older adults, with fentanyl, cocaine, and alcohol as the leading substances involved.
- Key findings indicate common health issues such as heart disease, chronic pain, and depression among victims, highlighting the need for targeted prevention efforts due to high healthcare contact rates prior to death.
Imaging mass cytometry reveals tissue-specific cellular immune phenotypes in the mouse knee following ACL injury.
Osteoarthr Cartil Open
December 2023
Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA.
Objective: To develop an imaging mass cytometry method for identifying complex cell phenotypes, inter-cellular interactions, and population changes in the synovium and infrapatellar fat pad (IFP) of the mouse knee following a non-invasive compression injury.
Design: Fifteen male C57BL/6 mice were fed a high-fat diet for 8 weeks prior to random assignment to sham, 0.88 mm, or 1.
generated antibodies guide thermostable ADDomer nanoparticle design for nasal vaccination and passive immunization against SARS-CoV-2.
Antib Ther
October 2023
Max Planck Bristol Centre for Minimal Biology, University of Bristol, Bristol BS8 1TS, UK.
Background: Due to COVID-19, pandemic preparedness emerges as a key imperative, necessitating new approaches to accelerate development of reagents against infectious pathogens.
Methods: Here, we developed an integrated approach combining synthetic, computational and structural methods with antibody selection and immunization to design, produce and validate nature-inspired nanoparticle-based reagents against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Results: Our approach resulted in two innovations: (i) a thermostable nasal vaccine called ADDoCoV, displaying multiple copies of a SARS-CoV-2 receptor binding motif derived epitope and (ii) a multivalent nanoparticle superbinder, called Gigabody, against SARS-CoV-2 including immune-evasive variants of concern (VOCs).
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