Introduction: Phytotherapy has been drawing interest from the scientific community regarding its potential wound healing properties. There are few studies available that present a correct scientific methodology and, therefore, phytotherapy remains an open field for further research.
Purpose: To evaluate the effects of Jatropha gossypiifolia L. (bellyache bush) on the healing of colonic anastomosis in rats.
Methods: Forty Wistar rats were subjected to a complete section of the colon, that was soon sutured with eight separate stitches using monofilament polypropylene 6-0. Randomly, the animals were divided into control group (CG), with 20 rats, which were injected with 0.9% sodium chloride solution intraperitoneally (1 mL/kg) and Jatropha group (JG), also with 20 rats, which were injected with Jatropha gossypiifolia L. alcoholic extract intraperitoneally (1 mL/kg). Each of the groups was subdivided into two subgroups of ten rats, according to the sacrifice date, third and seventh days (CG3/ CG7 and JG3/ JG7). After sacrifice, the segment of the colon containing 1cm proximal and distal to the site of anastomosis was removed and subjected to the pressure test with air insulation. This segment was then opened and a 1.0 x 0.5 cm part was removed and placed under 10% formaldehyde for histological analysis with hematoxylin-eosin and Masson's trichrome stainings.
Results: The evaluation of the pressure rupture test demonstrated statistical significance regarding the sacrifice date. On the third day, the average pressure of the CG (25.4 mmHg) and the JG (76.4 mmHg) revealed p = 0.013, and on the seventh day, the average pressure of the CG (187,3 mmHg.) and the JG (135.1 mmHg.) revealed p = 0.014. When assessing the microscopic variables among the groups of the 3rd day, only the variables edema and polymorphonuclear cells did not show statistical differences. On the 7th day, all of the variables assessed demonstrated significant differences.
Conclusions: Regarding mechanical resistance, there was a difference in resistance between the JG3 and the CG3, and a shift of resistance when comparing the JG7 and CG7, which suggests a weakening of the Jatropha effect at a later stage of healing. The histological evaluation revealed an improvement of the acute inflammatory process in the JG3 when compared to the CG3, which was even more intense during the chronic stage, when the two groups are compared on the seventh day. The histological study of the inflammatory process, in general, showed a favorable effect to the Jatropha group compared to the control group.
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http://dx.doi.org/10.1590/s0102-86502006000900012 | DOI Listing |
J Ethnopharmacol
August 2024
Laboratory of Technology and Pharmaceutical Biotechnology (Tecbiofar), Faculty of Pharmacy, Federal University of Rio Grande do Norte (UFRN), 59012-570, Natal, RN, Brazil. Electronic address:
Ethnopharmacological Relevance: The species Jatropha gossypiifolia, popularly known as "pinhão-roxo", is distributed throughout Brazil, is commonly employed for topical or oral administration in treating wounds, inflammations, and snake bites. Given the significant impact of snakebites on public health and the limitations of antivenom, coupled with the diverse molecular composition of this plant species, investigating its healing and antidermonecrotic capacities is relevant.
Aim Of The Study: This study aimed to develop a topical nanoemulsion incorporating the hydroethanolic extract of J.
Genetica
February 2024
Laboratory of Plant Genetics and Biotechnology, Department of Genetics, Federal University of Pernambuco (UFPE), Recife, PE, 50670-423, Brazil.
Satellite DNAs (satDNAs) are highly repetitive sequences that occur in virtually all eukaryotic genomes and can undergo rapid copy number and nucleotide sequence variation among relatives. After chromosomal mapping of the satDNA JcSAT1, it was found a large accumulation at subtelomeres of Jatropha curcas (subgenus Curcas), but an absence of these monomers in J. integerrima (subgenus Jatropha).
View Article and Find Full Text PDFCurr Ther Res Clin Exp
September 2023
Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon.
Background: Acetaminophen-induced liver injury remains a significant public health problem because available treatments are limited due to their adverse effects. Medicinal plants, which are an important source of bioactive molecules, could be an alternative treatment for liver disease.
Objective: This study was designed to investigate the curative effect of aqueous extracts of (Vitaceae) and (Euphorbiaceae) on acetaminophen-induced liver injury in mice.
Plant Biol (Stuttg)
October 2023
Department of Biology, Faculty of Mathematics and Natural Sciences, IPB University, Bogor, West Java, Indonesia.
Jatropha, a traditional medicinal plant known for its anti-inflammatory, antimicrobial, anticancer, antiviral, antidiabetic, and anticoagulant properties, was the subject of our study. We examined the morphology and chemical composition of three Jatropha species using cross- and longitudinal sections of fresh samples, observed with light microscopy. Histochemical analysis was conducted using various reagents to reveal the metabolites present.
View Article and Find Full Text PDFPlants (Basel)
July 2023
Environmental and Computational Chemistry Group, School of Pharmaceutical Sciences, Zaragocilla Campus, University of Cartagena, Cartagena 130014, Colombia.
The utilization of plants with medicinal properties is deeply rooted in the traditional knowledge of diverse human populations. This study aims to investigate the cytotoxicity of nine plants commonly used by communities in San Basilio de Palenque, Bolivar (Colombia), for managing inflammation-related illnesses. Hydroethanolic extracts from various plant parts such as roots, stems, barks, or leaves were prepared through a process involving drying, powdering, and maceration in an ethanol-water (7:3) solution.
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